Protein profile

KP13_02412

Ribosome-associated inhibitor A

Genome: KpKP13

Gene: raiA AHE43151.1 Structure source: AlphaFold + ColabFold UniProt W8VF28
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Amino acids 125
Annotations 4
Features 14
PDB binders 0
Druggability 0.356

Overview

Basic information about this protein and its source genome.

Accession
KP13_02412
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
raiA AHE43151.1
Status
annotated
Amino acids
125
Structure source
AlphaFold + ColabFold
GO
GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. GO:0022627 The small subunit of a ribosome located in the cytosol. GO:0043024 Binding to a small ribosomal subunit. GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
81.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.356
Structure W8VF28
Pocket Pocket 6
P2Rank 0.017
Structure W8VF28
Pocket Pocket 1
ColabFold model
FPocket 0.159 · Pocket 7
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 141 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
  • GO:0022627 The small subunit of a ribosome located in the cytosol.
  • GO:0043024 Binding to a small ribosomal subunit.
  • GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
105 125 MobiDBLite mobidb-lite consensus disorder prediction
18 105 CDD cd00552 RaiA
18 105 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
105 119 MobiDBLite mobidb-lite consensus disorder prediction
15 120 FunFam G3DSA:3.30.160.100:FF:000002 Ribosome-associated translation inhibitor RaiA
18 105 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein
15 119 Gene3D G3DSA:3.30.160.100 -
15 119 InterPro IPR036567 Ribosome hibernation promotion factor-like
17 119 SUPERFAMILY SSF69754 Ribosome binding protein Y (YfiA homologue)
17 119 InterPro IPR036567 Ribosome hibernation promotion factor-like
15 111 NCBIfam TIGR00741 ribosome-associated translation inhibitor RaiA
15 111 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
78 105 Coils Coil Coil
10 111 PANTHER PTHR33231 30S RIBOSOMAL PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_W8VF28
AlphaFold — — full sequence — Viewing
ColabFold KP13_02412
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.356