Protein profile

KP13_02411

putative lipoprotein

Genome: KpKP13

Gene: AHE43152.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWW7
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Amino acids 245
Annotations 4
Features 23
PDB binders 0
Druggability 0.367

Overview

Basic information about this protein and its source genome.

Accession
KP13_02411
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43152.1
Status
annotated
Amino acids
245
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:1990063 Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex. GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.878
DEG E-value
1.64e-173
Localization
OuterMembrane
ColabFold pLDDT
91.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.367
Structure A0A0H3GWW7
Pocket Pocket 1
P2Rank 0.178
Structure A0A0H3GWW7
Pocket Pocket 1
ColabFold model
FPocket 0.898 · Pocket 3
P2Rank 0.146 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 120 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005515 Binding to a protein.
  • GO:1990063 Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex.
  • GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
29 245 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
29 245 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
29 245 FunFam G3DSA:1.25.40.10:FF:000015 Outer membrane protein assembly factor BamD
19 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
5 244 NCBIfam TIGR03302 outer membrane protein assembly factor BamD
5 244 InterPro IPR017689 Outer membrane protein assembly factor BamD
23 245 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
27 121 SUPERFAMILY SSF48452 TPR-like
27 121 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
4 242 Hamap MF_00922 Outer membrane protein assembly factor BamD [bamD].
4 242 InterPro IPR017689 Outer membrane protein assembly factor BamD
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 242 PANTHER PTHR37423 SOLUBLE LYTIC MUREIN TRANSGLYCOSYLASE-RELATED
28 236 Pfam PF13525 Outer membrane lipoprotein
28 236 InterPro IPR039565 Outer membrane lipoprotein BamD-like
31 241 CDD cd15830 BamD
31 241 InterPro IPR017689 Outer membrane protein assembly factor BamD
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWW7
AlphaFold — — full sequence — Viewing
ColabFold KP13_02411
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.367

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.19 0.171
2 0.76 0.002