Protein profile

KP13_00807

Sigma-E factor negative regulatory protein

Genome: KpKP13

Gene: rseA AHE43172.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW95
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Amino acids 228
Annotations 2
Features 15
PDB binders 0
Druggability 0.8

Overview

Basic information about this protein and its source genome.

Accession
KP13_00807
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rseA AHE43172.1
Status
annotated
Amino acids
228
Structure source
AlphaFold + ColabFold
GO
GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
46.97
DEG E-value
3.37e-48
Localization
Unknown
ColabFold pLDDT
74.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.8
Structure A0A0H3GW95
Pocket Pocket 4
P2Rank
Structure A0A0H3GW95
Pocket No pockets
ColabFold model
FPocket 0.304 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 109 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
15 76 CDD cd16328 RseA_N
15 76 InterPro IPR005572 Anti sigma-E protein RseA, N-terminal
10 217 PIRSF PIRSF016938 RseA
10 217 InterPro IPR026279 Sigma-E factor negative regulatory protein RseA
175 195 Coils Coil Coil
181 202 Gene3D G3DSA:1.20.5.3960 -
144 198 Pfam PF03873 Anti sigma-E protein RseA, C-terminal domain
144 198 InterPro IPR005573 Anti sigma-E protein RseA, C-terminal
14 216 PANTHER PTHR38104 -
13 98 Pfam PF03872 Anti sigma-E protein RseA, N-terminal domain
13 98 InterPro IPR005572 Anti sigma-E protein RseA, N-terminal
181 202 FunFam G3DSA:1.20.5.3960:FF:000001 Anti-sigma-E factor RseA
13 78 SUPERFAMILY SSF89069 N-terminal, cytoplasmic domain of anti-sigmaE factor RseA
13 78 InterPro IPR036147 Anti sigma-E protein RseA, N-terminal domain superfamily
13 78 Gene3D G3DSA:1.10.10.880 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW95
AlphaFold — — full sequence — Viewing
ColabFold KP13_00807
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.8
7 0.419