Protein profile

KP13_00834

Tetratricopeptide repeat-containing protein

Genome: KpKP13

Gene: AHE43198.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW73
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Amino acids 1091
Annotations 2
Features 28
PDB binders 0
Druggability 0.736

Overview

Basic information about this protein and its source genome.

Accession
KP13_00834
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43198.1
Status
annotated
Amino acids
1091
Structure source
AlphaFold + ColabFold
GO
GO:0005515 Binding to a protein. GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
95.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.736
Structure A0A0H3GW73
Pocket Pocket 12
P2Rank 0.983
Structure A0A0H3GW73
Pocket Pocket 1
ColabFold model
FPocket 0.924 · Pocket 1
P2Rank 0.984 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 27 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005515 Binding to a protein.
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

28 records
Show feature table
Start End DB Term Name
748 1074 PANTHER PTHR12558 CELL DIVISION CYCLE 16,23,27
447 661 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
447 661 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
40 344 Pfam PF17128 Domain of unknown function (DUF5107)
40 344 InterPro IPR033396 Domain of unknown function DUF5107
744 777 ProSiteProfiles PS50005 TPR repeat profile.
744 777 InterPro IPR019734 Tetratricopeptide repeat
568 601 SMART SM00028 tpr_5
568 601 InterPro IPR019734 Tetratricopeptide repeat
778 812 SMART SM00028 tpr_5
778 812 InterPro IPR019734 Tetratricopeptide repeat
602 635 SMART SM00028 tpr_5
602 635 InterPro IPR019734 Tetratricopeptide repeat
744 777 SMART SM00028 tpr_5
935 968 SMART SM00028 tpr_5
935 968 InterPro IPR019734 Tetratricopeptide repeat
979 1012 SMART SM00028 tpr_5
979 1012 InterPro IPR019734 Tetratricopeptide repeat
482 627 SUPERFAMILY SSF48452 TPR-like
482 627 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
681 832 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
681 832 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
742 1009 SUPERFAMILY SSF48452 TPR-like
742 1009 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
893 1086 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
893 1086 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
903 963 Pfam PF13432 Tetratricopeptide repeat
574 633 Pfam PF13432 Tetratricopeptide repeat

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW73
AlphaFold — — full sequence — Viewing
ColabFold KP13_00834
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.736
42 0.274
69 0.007
3 0.002

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 61.32 0.983
2 47.71 0.964
3 12.94 0.586
4 11.89 0.545
5 10.54 0.487