Protein profile

KP13_00851

Protein iscX

Genome: KpKP13

Gene: AHE43215.1 iscX Structure source: AlphaFold + ColabFold UniProt A0A0H3GRN9
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Amino acids 66
Annotations 1
Features 12
PDB binders 0
Druggability 0.098

Overview

Basic information about this protein and its source genome.

Accession
KP13_00851
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43215.1 iscX
Status
annotated
Amino acids
66
Structure source
AlphaFold + ColabFold
GO
GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.098
Structure A0A0H3GRN9
Pocket Pocket 2
P2Rank
Structure A0A0H3GRN9
Pocket No pockets
ColabFold model
FPocket 0.061 · Pocket 2
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 204 / 4744 genomes with a hit
Normalized 0.043

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
3 66 Pfam PF04384 Iron-sulphur cluster assembly
3 66 InterPro IPR007479 ISC system FeS cluster assembly, IscX
1 66 FunFam G3DSA:1.10.10.600:FF:000001 Fe-S assembly protein IscX
3 64 SUPERFAMILY SSF140319 IscX-like
3 64 InterPro IPR036762 IscX-like superfamily
3 66 PIRSF PIRSF039003 IscX
4 66 NCBIfam TIGR03412 Fe-S cluster assembly protein IscX
4 66 InterPro IPR007479 ISC system FeS cluster assembly, IscX
1 66 Gene3D G3DSA:1.10.10.600 -
1 66 InterPro IPR036762 IscX-like superfamily
1 66 PANTHER PTHR37532 PROTEIN ISCX
1 66 InterPro IPR007479 ISC system FeS cluster assembly, IscX

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GRN9 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRN9
AlphaFold — — full sequence — Viewing
ColabFold KP13_00851
ColabFold — — full sequence — Loaded