Protein profile

KP13_00856

putative lipoprotein

Genome: KpKP13

Gene: AHE43219.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRN4
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Amino acids 1649
Annotations 2
Features 41
PDB binders 0
Druggability 0.307

Overview

Basic information about this protein and its source genome.

Accession
KP13_00856
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43219.1
Status
annotated
Amino acids
1649
Structure source
AlphaFold + ColabFold
GO
GO:0004866 Binds to and stops, prevents or reduces the activity of an endopeptidase. GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
26.119
Human E-value
3.54e-06
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
83.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.307
Structure A0A0H3GRN4
Pocket Pocket 1
P2Rank 0.759
Structure A0A0H3GRN4
Pocket Pocket 1
ColabFold model
FPocket 0.53 · Pocket 142
P2Rank 0.85 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 105 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004866 Binds to and stops, prevents or reduces the activity of an endopeptidase.
  • GO:0005615 OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

Sequence Features

Domain/signature hits from InterPro and related databases.

41 records
Show feature table
Start End DB Term Name
1170 1434 CDD cd02891 A2M_like
1 30 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
482 607 Pfam PF17972 Bacterial Alpha-2-macroglobulin MG5 domain
482 607 InterPro IPR041203 Bacterial Alpha-2-macroglobulin, MG5 domain
1 1649 PIRSF PIRSF038980 A2M_bac
1 1649 InterPro IPR026284 Alpha-2-macroglobulin, bacteria
965 1054 SMART SM01360 A2M_2
965 1054 InterPro IPR001599 Alpha-2-macroglobulin
385 476 Pfam PF01835 MG2 domain
385 476 InterPro IPR002890 Macroglobulin domain
286 378 Pfam PF11974 Bacterial alpha-2-macroglobulin MG3 domain
286 378 InterPro IPR021868 Alpha-2-macroglobulin MG3 domain
756 902 Pfam PF07703 Alpha-2-macroglobulin bait region domain
756 902 InterPro IPR011625 Alpha-2-macroglobulin, bait region domain
1174 1430 SUPERFAMILY SSF48239 Terpenoid cyclases/Protein prenyltransferases
1174 1430 InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
1173 1202 SMART SM01419 Thiol_ester_cl_2
1173 1202 InterPro IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region
384 480 Gene3D G3DSA:2.60.40.1930 -
56 160 Pfam PF17970 Bacterial Alpha-2-macroglobulin MG1 domain
56 160 InterPro IPR040639 Alpha-2-macroglobulin, MG1 domain
1501 1634 Pfam PF17973 Bacterial Alpha-2-macroglobulin MG10 domain
1501 1634 InterPro IPR041246 Bacterial alpha-2-macroglobulin MG10 domain
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1174 1283 Pfam PF07678 A-macroglobulin TED domain
1174 1283 InterPro IPR011626 Alpha-macroglobulin-like, TED domain
6 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
56 1641 PANTHER PTHR40094 ALPHA-2-MACROGLOBULIN HOMOLOG
613 738 Pfam PF17962 Bacterial macroglobulin domain 6
613 738 InterPro IPR041462 Bacterial Alpha-2-macroglobulin, MG6 domain
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 22 SignalP_EUK SignalP-noTM SignalP-noTM
1169 1436 Gene3D G3DSA:1.50.10.20 -
755 903 SMART SM01359 A2M_N_2_2
755 903 InterPro IPR011625 Alpha-2-macroglobulin, bait region domain
973 1054 Pfam PF00207 Alpha-2-macroglobulin family
973 1054 InterPro IPR001599 Alpha-2-macroglobulin
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
23 1649 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 22 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRN4
AlphaFold — — full sequence — Viewing
ColabFold KP13_00856
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.307

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.39 0.609
2 7.42 0.389
3 5.68 0.274
4 4.74 0.209
5 4.47 0.19