Protein profile

KP13_00860

Cytoskeleton protein rodZ

Genome: KpKP13

Gene: rodZ AHE43223.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWN6
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Amino acids 331
Annotations 4
Features 22
PDB binders 0
Druggability 0.457

Overview

Basic information about this protein and its source genome.

Accession
KP13_00860
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rodZ AHE43223.1
Status
annotated
Amino acids
331
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008360 Any process that modulates the surface configuration of a cell. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
77.419
DEG E-value
2.23e-178
Localization
Unknown
ColabFold pLDDT
70.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.457
Structure A0A0H3GWN6
Pocket Pocket 1
P2Rank
Structure A0A0H3GWN6
Pocket No pockets
ColabFold model
FPocket 0.231 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 93 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008360 Any process that modulates the surface configuration of a cell.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
144 241 MobiDBLite mobidb-lite consensus disorder prediction
134 331 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
18 79 SMART SM00530 mbf_short4
18 79 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
18 79 Pfam PF13413 Helix-turn-helix domain
249 323 Pfam PF13464 Domain of unknown function (DUF4115)
249 323 InterPro IPR025194 Domain of unknown function DUF4115
16 79 CDD cd00093 HTH_XRE
16 79 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 21 MobiDBLite mobidb-lite consensus disorder prediction
14 80 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
14 80 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
1 111 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
19 48 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
19 48 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
1 326 Hamap MF_02017 Cytoskeleton protein RodZ [rodZ].
1 326 InterPro IPR023690 Cytoskeleton protein RodZ
111 133 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
112 133 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 110 Gene3D G3DSA:1.10.260.40 -
4 110 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
3 325 PANTHER PTHR34475 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWN6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00860
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.457