Protein profile

KP13_00863

hypothetical protein

Genome: KpKP13

Gene: AHE43226.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTK6
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Amino acids 206
Annotations 3
Features 14
PDB binders 0
Druggability 0.395

Overview

Basic information about this protein and its source genome.

Accession
KP13_00863
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43226.1
Status
annotated
Amino acids
206
Structure source
AlphaFold + ColabFold
GO
GO:0044877 Binding to a macromolecular complex. GO:0005515 Binding to a protein. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
75.243
DEG E-value
3.92e-115
Localization
Periplasmic
ColabFold pLDDT
93.14

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.395
Structure A0A0H3GTK6
Pocket Pocket 5
P2Rank
Structure A0A0H3GTK6
Pocket No pockets
ColabFold model
FPocket 0.21 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 93 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0044877 Binding to a macromolecular complex.
  • GO:0005515 Binding to a protein.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
91 191 SUPERFAMILY SSF48452 TPR-like
91 191 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
24 42 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
43 206 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 23 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
31 203 Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
31 203 InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
24 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 205 PANTHER PTHR38035 UPF0070 PROTEIN YFGM
1 205 InterPro IPR026039 Ancillary SecYEG translocon subunit YfgM
1 206 PIRSF PIRSF006170 YfgM
1 206 InterPro IPR026039 Ancillary SecYEG translocon subunit YfgM
15 205 Pfam PF09976 Tetratricopeptide repeat-like domain
15 205 InterPro IPR018704 Tetratricopeptide repeat-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTK6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00863
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.383
10 0.3
1 0.233
16 0.217