Protein profile

KP13_00866

putative oxidoreductase

Genome: KpKP13

Gene: AHE43229.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRM4
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Amino acids 359
Annotations 1
Features 5
PDB binders 0
Druggability 0.221

Overview

Basic information about this protein and its source genome.

Accession
KP13_00866
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43229.1
Status
annotated
Amino acids
359
Structure source
AlphaFold + ColabFold
GO
GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.221
Structure A0A0H3GRM4
Pocket Pocket 20
P2Rank 0.916
Structure A0A0H3GRM4
Pocket Pocket 1
ColabFold model
FPocket 0.768 · Pocket 11
P2Rank 0.769 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 25 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0000166 Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
1 126 Gene3D G3DSA:3.40.50.720 -
3 106 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold
3 106 InterPro IPR000683 Gfo/Idh/MocA-like oxidoreductase, N-terminal
1 106 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
1 106 InterPro IPR036291 NAD(P)-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRM4
AlphaFold — — full sequence — Viewing
ColabFold KP13_00866
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.221

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 20.84 0.863
2 2.29 0.058
3 1.36 0.016
4 1.09 0.007