Protein profile

KP13_00868

Exodeoxyribonuclease 7 large subunit

Genome: KpKP13

Gene: xseA AHE43231.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTK1
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Amino acids 463
Annotations 6
Features 13
PDB binders 0
Druggability 0.29

Overview

Basic information about this protein and its source genome.

Accession
KP13_00868
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
xseA AHE43231.1
Status
annotated
Amino acids
463
Structure source
AlphaFold + ColabFold
EC
3.1.11.6
GO
GO:0008855 Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. GO:0003676 Binding to a nucleic acid. GO:0006308 The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. GO:0009318 An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.466
DEG E-value
1e-118
Localization
Cytoplasmic
ColabFold pLDDT
88.08

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.29
Structure A0A0H3GTK1
Pocket Pocket 1
P2Rank 0.086
Structure A0A0H3GTK1
Pocket Pocket 1
ColabFold model
FPocket 0.38 · Pocket 15
P2Rank 0.188 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 142 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0008855 Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides.
  • GO:0003676 Binding to a nucleic acid.
  • GO:0006308 The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
  • GO:0009318 An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
29 106 CDD cd04489 ExoVII_LU_OBF
29 106 InterPro IPR025824 OB-fold nucleic acid binding domain
312 332 Coils Coil Coil
11 358 NCBIfam TIGR00237 exodeoxyribonuclease VII large subunit
11 358 InterPro IPR003753 Exonuclease VII, large subunit
4 447 PANTHER PTHR30008 EXODEOXYRIBONUCLEASE 7 LARGE SUBUNIT
4 447 InterPro IPR003753 Exonuclease VII, large subunit
126 440 Pfam PF02601 Exonuclease VII, large subunit
126 440 InterPro IPR020579 Exonuclease VII, large subunit, C-terminal
7 443 Hamap MF_00378 Exodeoxyribonuclease 7 large subunit [xseA].
7 443 InterPro IPR003753 Exonuclease VII, large subunit
10 103 Pfam PF13742 OB-fold nucleic acid binding domain
10 103 InterPro IPR025824 OB-fold nucleic acid binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTK1
AlphaFold — — full sequence — Viewing
ColabFold KP13_00868
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.29

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.32 0.059
2 1.44 0.019
3 1.28 0.013