Protein profile

KP13_00871

Putative prophage CPS-53 integrase

Genome: KpKP13

Gene: AHE43234.1 intS Structure source: AlphaFold + ColabFold UniProt A0AB73W7X5
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Amino acids 416
Annotations 3
Features 18
PDB binders 0
Druggability 0.083

Overview

Basic information about this protein and its source genome.

Accession
KP13_00871
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43234.1 intS
Status
annotated
Amino acids
416
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.63

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.083
Structure A0AB73W7X5
Pocket Pocket 26
P2Rank 0.128
Structure A0AB73W7X5
Pocket Pocket 1
ColabFold model
FPocket 0.273 · Pocket 17
P2Rank 0.169 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 31 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
114 148 Pfam PF14659 Phage integrase, N-terminal SAM-like domain
114 148 InterPro IPR004107 Integrase, SAM-like, N-terminal
206 390 CDD cd00801 INT_P4_C
199 393 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
199 393 InterPro IPR013762 Integrase-like, catalytic domain superfamily
100 198 Gene3D G3DSA:1.10.150.130 -
100 198 InterPro IPR010998 Integrase/recombinase, N-terminal
1 99 Gene3D G3DSA:3.30.160.390 -
1 99 InterPro IPR038488 Integrase, DNA-binding domain superfamily
199 383 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
199 383 InterPro IPR002104 Integrase, catalytic domain
2 398 PANTHER PTHR30629 PROPHAGE INTEGRASE
2 87 Pfam PF13356 Arm DNA-binding domain
2 87 InterPro IPR025166 Integrase, DNA-binding domain
204 374 Pfam PF00589 Phage integrase family
204 374 InterPro IPR002104 Integrase, catalytic domain
98 383 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
98 383 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0AB73W7X5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00871
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.18 0.052