Protein profile

KP13_00927

putative arylsulfatase regulator

Genome: KpKP13

Gene: AHE43290.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTJ6
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Amino acids 392
Annotations 5
Features 25
PDB binders 0
Druggability 0.611

Overview

Basic information about this protein and its source genome.

Accession
KP13_00927
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43290.1
Status
annotated
Amino acids
392
Structure source
AlphaFold + ColabFold
GO
GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.308
DEG E-value
2.52e-111
Localization
Cytoplasmic
ColabFold pLDDT
94.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.611
Structure A0A0H3GTJ6
Pocket Pocket 2
P2Rank 0.924
Structure A0A0H3GTJ6
Pocket Pocket 1
ColabFold model
FPocket 0.654 · Pocket 19
P2Rank 0.988 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
309 330 ProSitePatterns PS00028 Zinc finger C2H2 type domain signature.
309 330 InterPro IPR013087 Zinc finger C2H2-type
14 322 SUPERFAMILY SSF102114 Radical SAM enzymes
1 233 ProSiteProfiles PS51918 Radical SAM core domain profile.
1 233 InterPro IPR007197 Radical SAM
253 339 NCBIfam TIGR04085 SPASM domain
253 339 InterPro IPR023885 4Fe4S-binding SPASM domain
246 351 CDD cd21120 SPASM_anSME
246 351 InterPro IPR047207 Anaerobic sulfatase maturating enzyme, SPASM domain
14 164 Pfam PF04055 Radical SAM superfamily
14 164 InterPro IPR007197 Radical SAM
3 373 SFLD SFLDS00029 Radical SAM
3 373 InterPro IPR007197 Radical SAM
3 373 SFLD SFLDF00285 anaerobic Ser-type sulfatase-maturating enzyme
3 373 InterPro IPR034491 Anaerobic Ser-type sulfatase-maturating enzyme
253 313 Pfam PF13186 Iron-sulfur cluster-binding domain
253 313 InterPro IPR023885 4Fe4S-binding SPASM domain
13 165 CDD cd01335 Radical_SAM
3 360 Gene3D G3DSA:3.20.20.70 Aldolase class I
3 360 InterPro IPR013785 Aldolase-type TIM barrel
14 336 SFLD SFLDG01384 thioether bond formation requiring two auxiliary iron-sulfur clusters
14 336 InterPro IPR023867 Anaerobic sulphatase maturase, radical SAM
3 372 PANTHER PTHR43273 ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED
3 372 InterPro IPR023867 Anaerobic sulphatase maturase, radical SAM
7 358 NCBIfam TIGR03942 anaerobic sulfatase maturase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTJ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00927
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
23 0.181
4 0.026
1 0.004
16 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 34.16 0.924
2 15.63 0.677
3 5.42 0.212
4 4.51 0.159
5 1.84 0.03