Protein profile

KP13_03823

Glycine cleavage system transcriptional repressor

Genome: KpKP13

Gene: gcvR AHE43307.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTH7
Export view
Amino acids 210
Annotations 2
Features 14
PDB binders 0
Druggability 0.473

Overview

Basic information about this protein and its source genome.

Accession
KP13_03823
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
gcvR AHE43307.1
Status
annotated
Amino acids
210
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
84.656
DEG E-value
1.02e-115
Localization
Cytoplasmic
ColabFold pLDDT
83.49

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.473
Structure A0A0H3GTH7
Pocket Pocket 2
P2Rank 0.019
Structure A0A0H3GTH7
Pocket Pocket 1
ColabFold model
FPocket 0.154 · Pocket 9
P2Rank 0.039 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
26 110 FunFam G3DSA:3.30.70.260:FF:000005 Glycine cleavage system transcriptional repressor
25 110 Gene3D G3DSA:3.30.70.260 -
113 209 Gene3D G3DSA:3.30.70.260 -
119 197 ProSiteProfiles PS51671 ACT domain profile.
119 197 InterPro IPR002912 ACT domain
28 108 SUPERFAMILY SSF55021 ACT-like
28 108 InterPro IPR045865 ACT-like domain
28 206 PANTHER PTHR34875 UPF0237 PROTEIN MJ1558
27 201 PIRSF PIRSF028103 GcvR
27 201 InterPro IPR016867 Glycine cleavage system transcriptional repressor
113 200 SUPERFAMILY SSF55021 ACT-like
113 200 InterPro IPR045865 ACT-like domain
30 106 CDD cd04893 ACT_GcvR_1
29 104 Pfam PF13740 ACT domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTH7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03823
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.01
4 0.003
8 0.002
10 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.55 0.019