Protein profile

KP13_03825

Lipoprotein 34

Genome: KpKP13

Gene: AHE43309.1 nlpB Structure source: AlphaFold + ColabFold UniProt A0A0H3GWJ5
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Amino acids 310
Annotations 3
Features 9
PDB binders 0
Druggability 0.558

Overview

Basic information about this protein and its source genome.

Accession
KP13_03825
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43309.1 nlpB
Status
annotated
Amino acids
310
Structure source
AlphaFold + ColabFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
OuterMembrane
ColabFold pLDDT
89.53

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.558
Structure A0A0H3GWJ5
Pocket Pocket 10
P2Rank 0.165
Structure A0A0H3GWJ5
Pocket Pocket 1
ColabFold model
FPocket 0.518 · Pocket 5
P2Rank 0.029 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 92 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
67 177 Gene3D G3DSA:3.30.530.50 -
7 308 Pfam PF06804 NlpB/DapX lipoprotein
7 308 InterPro IPR010653 NlpB/DapX lipoprotein
192 310 Gene3D G3DSA:3.30.310.170 Outer membrane protein assembly factor BamC
192 310 InterPro IPR042268 Outer membrane protein assembly factor BamC, C-terminal
1 310 PIRSF PIRSF026343 NlpB
1 310 InterPro IPR014524 Outer membrane protein assembly factor BamC
2 310 Hamap MF_00924 Outer membrane protein assembly factor BamC [bamC].
2 310 InterPro IPR014524 Outer membrane protein assembly factor BamC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWJ5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03825
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.017
5 0.001
4 0.0
11 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.62 0.165
2 1.61 0.021