Protein profile

KP13_03832

thioredoxin domain-containing protein

Genome: KpKP13

Gene: AHE43316.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTG7
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Amino acids 114
Annotations 0
Features 12
PDB binders 0
Druggability 0.295

Overview

Basic information about this protein and its source genome.

Accession
KP13_03832
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43316.1
Status
annotated
Amino acids
114
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
77.477
DEG E-value
4.21e-64
Localization
Unknown
ColabFold pLDDT
95.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.295
Structure A0A0H3GTG7
Pocket Pocket 3
P2Rank 0.072
Structure A0A0H3GTG7
Pocket Pocket 1
ColabFold model
FPocket 0.566 · Pocket 4
P2Rank 0.071 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 125 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 113 Gene3D G3DSA:3.40.30.10 Glutaredoxin
2 111 Pfam PF03960 ArsC family
2 111 InterPro IPR006660 Arsenate reductase-like
2 105 CDD cd03035 ArsC_Yffb
1 112 NCBIfam TIGR01617 Spx/MgsR family RNA polymerase-binding regulatory protein
1 112 InterPro IPR006504 Transcriptional regulator Spx/MgsR
1 114 ProSiteProfiles PS51353 ArsC family profile.
1 114 InterPro IPR006660 Arsenate reductase-like
1 111 PANTHER PTHR30041 ARSENATE REDUCTASE
1 111 InterPro IPR006660 Arsenate reductase-like
1 111 SUPERFAMILY SSF52833 Thioredoxin-like
1 111 InterPro IPR036249 Thioredoxin-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTG7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03832
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.295