Protein profile

KP13_03842

Ethanolamine utilization protein eutP

Genome: KpKP13

Gene: AHE43326.1 eutP Structure source: AlphaFold + ColabFold UniProt A0A0H3GTF9
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Amino acids 159
Annotations 2
Features 13
PDB binders 0
Druggability 0.226

Overview

Basic information about this protein and its source genome.

Accession
KP13_03842
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43326.1 eutP
Status
annotated
Amino acids
159
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576 The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
74.051
DEG E-value
6.36e-84
Localization
Unknown
ColabFold pLDDT
89.34

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.226
Structure A0A0H3GTF9
Pocket Pocket 3
P2Rank 0.494
Structure A0A0H3GTF9
Pocket Pocket 1
ColabFold model
FPocket 0.259 · Pocket 1
P2Rank 0.496 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 33 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0006576 The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 149 PANTHER PTHR40453 PROTEIN YOEF
1 149 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV
2 143 NCBIfam TIGR02528 EutP/PduV family microcompartment system protein
2 143 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV
1 148 PIRSF PIRSF036409 EutP_PduV
1 148 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV
1 143 Pfam PF10662 Ethanolamine utilisation - propanediol utilisation
1 143 InterPro IPR012381 Ethanolamine/propanediol utilisation protein, EutP/PduV
3 146 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
3 146 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
5 144 CDD cd00882 Ras_like_GTPase
1 153 Gene3D G3DSA:3.40.50.300 -
1 153 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTF9
AlphaFold — — full sequence — Viewing
ColabFold KP13_03842
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.226

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.02 0.297
2 1.79 0.033