Protein profile

KP13_03852

Ethanolamine utilization protein eutA

Genome: KpKP13

Gene: eutA AHE43336.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GTE6
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Amino acids 467
Annotations 2
Features 7
PDB binders 0
Druggability 0.854

Overview

Basic information about this protein and its source genome.

Accession
KP13_03852
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
eutA AHE43336.1
Status
annotated
Amino acids
467
Structure source
AlphaFold + ColabFold
GO
GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0046336 The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.854
Structure A0A0H3GTE6
Pocket Pocket 1
P2Rank 0.942
Structure A0A0H3GTE6
Pocket Pocket 1
ColabFold model
FPocket 0.089 · Pocket 19
P2Rank 0.964 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 34 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
  • GO:0046336 The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
118 320 PANTHER PTHR32432 CELL DIVISION PROTEIN FTSA-RELATED
2 467 PIRSF PIRSF012293 EutA
2 467 InterPro IPR009377 Ethanolamine ammonia-lyase reactivase EutA
8 266 SUPERFAMILY SSF53067 Actin-like ATPase domain
8 266 InterPro IPR043129 ATPase, nucleotide binding domain
5 465 Pfam PF06277 Ethanolamine utilisation protein EutA
5 465 InterPro IPR009377 Ethanolamine ammonia-lyase reactivase EutA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTE6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03852
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.854

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.7 0.9
2 3.53 0.13
3 3.37 0.12
4 2.19 0.053
5 1.15 0.009