Protein profile

KP13_03533

Ethanolamine utilization protein eutK

Genome: KpKP13

Gene: AHE43339.1 eutK Structure source: AlphaFold + ColabFold UniProt A0A0H3H1A2
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Amino acids 161
Annotations 1
Features 20
PDB binders 2
Druggability 0.329

Overview

Basic information about this protein and its source genome.

Accession
KP13_03533
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43339.1 eutK
Status
annotated
Amino acids
161
Structure source
AlphaFold + ColabFold
GO
GO:0031469 An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
90.48

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.329
Structure A0A0H3H1A2
Pocket Pocket 10
P2Rank 0.012
Structure A0A0H3H1A2
Pocket Pocket 1
ColabFold model
FPocket 0.244 · Pocket 7
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 30 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0031469 An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
21 40 ProSitePatterns PS01139 Bacterial microcompartment (BMC) domain signature.
21 40 InterPro IPR020808 Bacterial microcompartments protein, conserved site
4 88 ProSiteProfiles PS51930 Bacterial microcompartment (BMC) domain profile.
4 88 InterPro IPR044872 CcmK/CsoS1, bacterial microcompartment domain
103 157 Pfam PF16365 Ethanolamine utilization protein EutK C-terminus
103 157 InterPro IPR032298 EutK-Ctail domain
3 79 SMART SM00877 BMC_2
3 79 InterPro IPR000249 Bacterial microcompartment domain
3 89 SUPERFAMILY SSF143414 CcmK-like
3 89 InterPro IPR037233 CcmK-like superfamily
103 161 Gene3D G3DSA:1.10.10.10 -
103 161 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
104 160 ProSiteProfiles PS51933 EutK-Ctail domain profile.
104 160 InterPro IPR032298 EutK-Ctail domain
2 157 PANTHER PTHR33941 PROPANEDIOL UTILIZATION PROTEIN PDUA
4 87 CDD cd07045 BMC_CcmK_like
4 79 Pfam PF00936 BMC domain
4 79 InterPro IPR000249 Bacterial microcompartment domain
1 95 Gene3D G3DSA:3.30.70.1710 -
1 95 InterPro IPR037233 CcmK-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H1A2
AlphaFold — — full sequence — Viewing
ColabFold KP13_03533
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.329

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.02 0.006

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

17 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FLC
3I71
P76540 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
TAR
4QIF
P0A1C7 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@H]([C@@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.