Protein profile

KP13_03541

Thiosulfate-binding protein

Genome: KpKP13

Gene: AHE43347.1 cysP Structure source: AlphaFold + ColabFold UniProt A0A0H3H193
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Amino acids 338
Annotations 4
Features 21
PDB binders 0
Druggability 0.302

Overview

Basic information about this protein and its source genome.

Accession
KP13_03541
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43347.1 cysP
Status
annotated
Amino acids
338
Structure source
AlphaFold + ColabFold
GO
GO:1901681 Binding to a sulfur compound. GO:0140104 Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. GO:1902358 The directed movement of sulfate across a membrane. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
92.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.302
Structure A0A0H3H193
Pocket Pocket 15
P2Rank 0.833
Structure A0A0H3H193
Pocket Pocket 1
ColabFold model
FPocket 0.624 · Pocket 14
P2Rank 0.834 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 124 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:1901681 Binding to a sulfur compound.
  • GO:0140104 Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location.
  • GO:1902358 The directed movement of sulfate across a membrane.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
38 286 Pfam PF13531 Bacterial extracellular solute-binding protein
120 332 Gene3D G3DSA:3.40.190.10 -
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
13 334 PANTHER PTHR30368 SULFATE-BINDING PROTEIN
13 334 InterPro IPR005669 Thiosulphate/Sulfate-binding protein
151 159 ProSitePatterns PS00757 Prokaryotic sulfate-binding proteins signature 2.
151 159 InterPro IPR034408 Sulphate/thiosulphate-binding site
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
53 65 ProSitePatterns PS00401 Prokaryotic sulfate-binding proteins signature 1.
53 65 InterPro IPR000957 Sulphate/thiosulphate-binding, conserved site
24 332 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
15 332 NCBIfam TIGR00971 sulfate ABC transporter substrate-binding protein
15 332 InterPro IPR005669 Thiosulphate/Sulfate-binding protein
26 338 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 332 CDD cd01005 PBP2_CysP
24 332 InterPro IPR005669 Thiosulphate/Sulfate-binding protein
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
28 301 Gene3D G3DSA:3.40.190.10 -
11 21 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
22 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 25 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H193
AlphaFold — — full sequence — Viewing
ColabFold KP13_03541
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.302

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.32 0.606
2 2.1 0.048
3 1.87 0.037
4 0.92 0.004