Protein profile

KP13_03542

Sulfate transport system permease protein cysT

Genome: KpKP13

Gene: AHE43348.1 cysU Structure source: AlphaFold + ColabFold UniProt A0A0H3GTC8
Export view
Amino acids 277
Annotations 5
Features 39
PDB binders 0
Druggability 0.866

Overview

Basic information about this protein and its source genome.

Accession
KP13_03542
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43348.1 cysU
Status
annotated
Amino acids
277
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015419 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008272 OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.385
DEG E-value
9.69e-62
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.0

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.866
Structure A0A0H3GTC8
Pocket Pocket 3
P2Rank 0.057
Structure A0A0H3GTC8
Pocket Pocket 1
ColabFold model
FPocket 0.871 · Pocket 3
P2Rank 0.035 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 186 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015419 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008272 OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

39 records
Show feature table
Start End DB Term Name
138 160 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
60 263 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
60 263 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
244 263 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
264 277 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
14 273 Gene3D G3DSA:1.10.3720.10 -
14 273 InterPro IPR035906 MetI-like superfamily
196 224 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
35 57 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
188 205 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
212 234 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
244 266 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
157 195 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
137 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
3 273 PANTHER PTHR30406 SULFATE TRANSPORT SYSTEM PERMEASE PROTEIN
3 273 InterPro IPR005667 Sulphate ABC transporter permease protein 2
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
104 125 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
9 271 NCBIfam TIGR02139 sulfate ABC transporter permease subunit CysT
9 271 InterPro IPR011865 Sulphate ABC transporter, permease protein CysT
16 264 SUPERFAMILY SSF161098 MetI-like
16 264 InterPro IPR035906 MetI-like superfamily
126 136 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
31 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
84 103 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 269 NCBIfam TIGR00969 sulfate ABC transporter permease subunit
5 269 InterPro IPR005667 Sulphate ABC transporter permease protein 2
62 84 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
14 272 FunFam G3DSA:1.10.3720.10:FF:000004 Sulfate transport system permease protein CysT
58 83 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
62 252 CDD cd06261 TM_PBP2
62 252 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
76 274 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
76 274 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
225 243 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GTC8
AlphaFold — — full sequence — Viewing
ColabFold KP13_03542
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.866

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.9 0.22
2 2.6 0.075
3 2.44 0.066
4 1.54 0.023
5 1.2 0.011