Protein profile

KP13_03543

Sulfate transport system permease protein cysW

Genome: KpKP13

Gene: AHE43349.1 cysW Structure source: AlphaFold + ColabFold UniProt A0A0H3GVX8
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Amino acids 291
Annotations 5
Features 36
PDB binders 0
Druggability 0.371

Overview

Basic information about this protein and its source genome.

Accession
KP13_03543
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43349.1 cysW
Status
annotated
Amino acids
291
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015419 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008272 OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
92.096
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.96

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.371
Structure A0A0H3GVX8
Pocket Pocket 17
P2Rank 0.079
Structure A0A0H3GVX8
Pocket Pocket 1
ColabFold model
FPocket 0.967 · Pocket 6
P2Rank 0.051 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 188 / 4744 genomes with a hit
Normalized 0.04

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015419 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008272 OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

36 records
Show feature table
Start End DB Term Name
81 273 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
81 273 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 275 NCBIfam TIGR00969 sulfate ABC transporter permease subunit
2 275 InterPro IPR005667 Sulphate ABC transporter permease protein 2
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
163 201 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
69 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
101 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 162 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
125 143 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 281 PANTHER PTHR30406 SULFATE TRANSPORT SYSTEM PERMEASE PROTEIN
1 281 InterPro IPR005667 Sulphate ABC transporter permease protein 2
20 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
90 100 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
229 247 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 268 SUPERFAMILY SSF161098 MetI-like
16 268 InterPro IPR035906 MetI-like superfamily
19 276 NCBIfam TIGR02140 sulfate ABC transporter permease subunit CysW
19 276 InterPro IPR011866 Sulphate ABC transporter, permease protein CysW
63 89 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
246 268 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
201 223 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 270 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
66 270 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
44 62 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
144 162 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 277 FunFam G3DSA:1.10.3720.10:FF:000015 Sulfate ABC transporter, permease CysW
202 228 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
248 268 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 276 Gene3D G3DSA:1.10.3720.10 -
21 276 InterPro IPR035906 MetI-like superfamily
269 291 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
66 263 CDD cd06261 TM_PBP2
66 263 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVX8
AlphaFold — — full sequence — Viewing
ColabFold KP13_03543
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.371
14 0.356
9 0.213

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.89 0.092
2 2.28 0.057
3 1.11 0.008