Overview
Basic information about this protein and its source genome.
- Accession
- KP13_03556
- Gene
- zipA AHE43362.1
- Status
- annotated
- Amino acids
- 353
- Structure source
- AlphaFold + ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Human identity (%)
- 0.0
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- DEG identity (%)
- 66.759
- DEG E-value
- 3.08e-131
- Localization
- CytoplasmicMembrane
- ColabFold pLDDT
- 72.12
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
6- GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
- GO:0090529 The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
- GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
- GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
- GO:0000917 The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.
- GO:0043093 A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 7 | 26 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 27 | 353 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 141 | 187 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 5 | 27 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 215 | 345 | SMART | SM00771 | ZipA_C_cls |
| 215 | 345 | InterPro | IPR007449 | ZipA, C-terminal FtsZ-binding domain |
| 216 | 345 | CDD | cd00231 | ZipA |
| 216 | 345 | InterPro | IPR007449 | ZipA, C-terminal FtsZ-binding domain |
| 108 | 131 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 3 | 347 | Hamap | MF_00509 | Cell division protein ZipA [zipA]. |
| 3 | 347 | InterPro | IPR011919 | Cell division protein ZipA |
| 1 | 6 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. |
| 213 | 353 | Gene3D | G3DSA:3.30.1400.10 | - |
| 213 | 353 | InterPro | IPR036765 | ZipA, C-terminal FtsZ-binding domain superfamily |
| 46 | 215 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 72 | 86 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 216 | 350 | SUPERFAMILY | SSF64383 | Cell-division protein ZipA, C-terminal domain |
| 216 | 350 | InterPro | IPR036765 | ZipA, C-terminal FtsZ-binding domain superfamily |
| 1 | 353 | PANTHER | PTHR38685 | CELL DIVISION PROTEIN ZIPA |
| 1 | 353 | InterPro | IPR011919 | Cell division protein ZipA |
| 213 | 353 | FunFam | G3DSA:3.30.1400.10:FF:000001 | Cell division protein ZipA |
| 218 | 344 | Pfam | PF04354 | ZipA, C-terminal FtsZ-binding domain |
| 218 | 344 | InterPro | IPR007449 | ZipA, C-terminal FtsZ-binding domain |
| 131 | 345 | NCBIfam | TIGR02205 | cell division protein ZipA |
| 131 | 345 | InterPro | IPR011919 | Cell division protein ZipA |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3GTB2
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_03556
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 10 | 0.308 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 7 | 0.717 | ||||||
| 2 | 0.261 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| CL3 | P77173 | 343.4 Da LogP 3.44 TPSA 63.4 | ✓ Ro5 | ✓ Clean |
CC(=O)N(C)c1cccc(c1)c2nnc3n2nc(cc3)c4ccccc4
|
|
| IQZ | P77173 | 240.3 Da LogP 2.89 TPSA 36.1 | ✓ Ro5 | ✓ Clean |
c1ccc2c(c1)c3c([nH]2)[C@@H]4CCCC[N@]4CC3=O
|
|
| WAC | P77173 | 403.5 Da LogP 3.08 TPSA 71.4 | ✓ Ro5 | ✓ Clean |
CC(C)S(=O)(=O)NCCCn1c2ccccc2c3c1[C@@H]4CCCC[N@]…
|
|
| WAI | P77173 | 424.0 Da LogP 3.32 TPSA 83.2 | ✓ Ro5 | ✓ Clean |
Cc1ccc(cc1Cl)Nc2nccc(n2)c3ccnc(c3)N4CCN(CC4)CCN
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
| Ligand | Tanimoto | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|
| ZINC105343 | 0.755 | 281.3 Da LogP 2.08 TPSA 63.4 | ✓ Ro5 | ✓ Clean |
CC(=O)N(C)c1cccc(-c2ccc3nnc(C)n3n2)c1
|
| ZINC1630521 | 0.533 | 212.3 Da LogP 2.86 TPSA 19.0 | ✓ Ro5 | Alert |
c1ccc2c3c([nH]c2c1)[C@@H]1CCCN1CC3
|
| ZINC6576349 | 0.533 | 212.3 Da LogP 2.86 TPSA 19.0 | ✓ Ro5 | Alert |
c1ccc2c3c([nH]c2c1)[C@H]1CCCN1CC3
|
| ZINC1417172 | 0.509 | 302.3 Da LogP 3.47 TPSA 52.3 | ✓ Ro5 | ✓ Clean |
COc1ccc(-c2nnc3ccc(-c4ccccc4)nn23)cc1
|
| ZINC1670185 | 0.500 | 226.3 Da LogP 3.08 TPSA 19.0 | ✓ Ro5 | Alert |
c1ccc2c3c([nH]c2c1)CN1CCCC[C@H]1C3
|
| ZINC20095944 | 0.500 | 210.2 Da LogP 2.10 TPSA 43.1 | ✓ Ro5 | ✓ Clean |
Cc1nnc2ccc(-c3ccccc3)nn12
|
| ZINC4783271 | 0.500 | 226.3 Da LogP 3.08 TPSA 19.0 | ✓ Ro5 | Alert |
c1ccc2c3c([nH]c2c1)CN1CCCC[C@@H]1C3
|
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.