Protein profile

KP13_03744

Cyanate transport protein cynX

Genome: KpKP13

Gene: AHE43383.1 cynX Structure source: AlphaFold + ColabFold UniProt A0A0H3GVV3
Export view
Amino acids 395
Annotations 2
Features 50
PDB binders 0
Druggability 0.939

Overview

Basic information about this protein and its source genome.

Accession
KP13_03744
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43383.1 cynX
Status
annotated
Amino acids
395
Structure source
AlphaFold + ColabFold
GO
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.939
Structure A0A0H3GVV3
Pocket Pocket 20
P2Rank 0.914
Structure A0A0H3GVV3
Pocket Pocket 1
ColabFold model
FPocket 0.885 · Pocket 9
P2Rank 0.937 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 23 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

50 records
Show feature table
Start End DB Term Name
17 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
381 395 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
163 184 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
130 152 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
270 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
205 227 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 386 PANTHER PTHR23523 -
101 123 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
120 130 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
347 360 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
361 380 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
74 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
131 151 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
6 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
361 380 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
239 258 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
317 327 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
40 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
228 238 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
203 386 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
203 386 InterPro IPR036259 MFS transporter superfamily
1 5 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
3 202 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
3 202 InterPro IPR036259 MFS transporter superfamily
162 181 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
289 293 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
92 96 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
294 316 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
328 346 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
259 269 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
25 39 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
209 231 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
23 343 Pfam PF07690 Major Facilitator Superfamily
23 343 InterPro IPR011701 Major facilitator superfamily
73 91 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
241 263 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
294 316 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
152 162 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 384 SUPERFAMILY SSF103473 MFS general substrate transporter
3 384 InterPro IPR036259 MFS transporter superfamily
62 72 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 383 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
1 383 InterPro IPR020846 Major facilitator superfamily domain
185 204 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
270 288 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
328 346 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
97 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVV3
AlphaFold — — full sequence — Viewing
ColabFold KP13_03744
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.939
4 0.736

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 25.39 0.906
2 3.08 0.103
3 2.85 0.089
4 1.27 0.013