Protein profile

KP13_03057

putative DotU-containing Type IV / VI secretion system protein

Genome: KpKP13

Gene: AHE43391.1 Structure source: AlphaFold + ColabFold UniProt A0A919LSH0
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Amino acids 229
Annotations 0
Features 12
PDB binders 0
Druggability 0.735

Overview

Basic information about this protein and its source genome.

Accession
KP13_03057
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43391.1
Status
annotated
Amino acids
229
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
82.23

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.735
Structure A0A919LSH0
Pocket Pocket 4
P2Rank 0.066
Structure A0A919LSH0
Pocket Pocket 1
ColabFold model
FPocket 0.445 · Pocket 8
P2Rank 0.135 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
2 181 Gene3D G3DSA:1.25.40.590 Type IV / VI secretion system, DotU
2 181 InterPro IPR038522 Type IV / VI secretion system, DotU superfamily
194 216 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
213 229 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 218 NCBIfam TIGR03349 DotU/TssL family secretion system protein
7 218 InterPro IPR017732 Type IV / VI secretion system, DotU
11 220 PANTHER PTHR38033 MEMBRANE PROTEIN-RELATED
6 221 NCBIfam NF038239 type VI secretion system protein TssL, short form
7 215 Pfam PF09850 Type VI secretion system protein DotU
7 215 InterPro IPR017732 Type IV / VI secretion system, DotU
194 212 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 193 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A919LSH0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03057
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.43
5 0.001
16 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.73 0.066
2 1.95 0.034
3 1.09 0.007
4 1.07 0.006
5 0.65 0.001