Protein profile

KP13_01067

ImcF-related protein

Genome: KpKP13

Gene: AHE43405.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EQ86
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Amino acids 1123
Annotations 0
Features 16
PDB binders 0
Druggability 0.769

Overview

Basic information about this protein and its source genome.

Accession
KP13_01067
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43405.1
Status
annotated
Amino acids
1123
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
81.67

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.769
Structure A0A6A8EQ86
Pocket Pocket 5
P2Rank 0.317
Structure A0A6A8EQ86
Pocket Pocket 1
ColabFold model
FPocket 0.871 · Pocket 5
P2Rank 0.173 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 12 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
9 29 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
165 1112 PANTHER PTHR36153 INNER MEMBRANE PROTEIN-RELATED
68 366 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
46 66 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
389 1123 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
49 67 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
988 1091 Pfam PF06744 Type VI secretion protein IcmF C2-like domain
988 1091 InterPro IPR010623 Type VI secretion system IcmF, C-terminal
629 649 Coils Coil Coil
1 8 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
367 388 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
366 388 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
420 730 Pfam PF06761 Intracellular multiplication and human macrophage-killing
420 730 InterPro IPR009612 IcmF-related
30 48 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EQ86
AlphaFold — — full sequence — Viewing
ColabFold KP13_01067
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
23 0.59
96 0.409
52 0.205

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.74 0.143
2 3.05 0.101
3 2.5 0.069
4 2.07 0.046
5 1.89 0.038