Protein profile

KP13_01061

Type VI secretion system VgrG family protein

Genome: KpKP13

Gene: AHE43411.1 Structure source: AlphaFold + ColabFold UniProt A0A6A8EQU7
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Amino acids 824
Annotations 0
Features 22
PDB binders 0
Druggability 0.643

Overview

Basic information about this protein and its source genome.

Accession
KP13_01061
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43411.1
Status
annotated
Amino acids
824
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.431
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.643
Structure A0A6A8EQU7
Pocket Pocket 64
P2Rank 0.106
Structure A0A6A8EQU7
Pocket Pocket 1
ColabFold model
FPocket 0.676 · Pocket 48
P2Rank 0.158 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
62 266 PANTHER PTHR32305 -
34 340 Pfam PF05954 Phage tail baseplate hub (GPD)
227 242 Gene3D G3DSA:4.10.180.10 -
99 194 Gene3D G3DSA:3.55.50.10 -
28 499 NCBIfam TIGR03361 type VI secretion system tip protein TssI/VgrG N-terminal domain
28 499 InterPro IPR017847 Type VI secretion system, RhsGE-associated Vgr family subset
604 728 Pfam PF10106 Uncharacterized protein conserved in bacteria (DUF2345)
604 728 InterPro IPR018769 Type VI secretion system spike protein VgrG2, domain of unknown function DUF2345
556 590 Coils Coil Coil
190 368 SUPERFAMILY SSF69279 Phage tail proteins
16 190 SUPERFAMILY SSF69279 Phage tail proteins
477 577 Pfam PF13296 Putative type VI secretion system Rhs element Vgr
477 577 InterPro IPR028244 Putative type VI secretion system, Rhs element associated Vgr domain
279 355 Gene3D G3DSA:2.30.110.50 -
367 456 SUPERFAMILY SSF69255 gp5 N-terminal domain-like
27 501 NCBIfam TIGR01646 type VI secretion system tip protein VgrG
27 501 InterPro IPR006533 Type VI secretion system, RhsGE-associated Vgr protein
373 455 Gene3D G3DSA:2.40.50.230 -
373 455 InterPro IPR037026 Vgr protein, OB-fold domain superfamily
391 457 Pfam PF04717 Type VI secretion system/phage-baseplate injector OB domain
391 457 InterPro IPR006531 Gp5/Type VI secretion system Vgr protein, OB-fold domain
27 243 Gene3D G3DSA:2.30.110.50 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6A8EQU7
AlphaFold — — full sequence — Viewing
ColabFold KP13_01061
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
64 0.643
11 0.465
3 0.346
56 0.328

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.73 0.082
2 2.59 0.074
3 2.1 0.048
4 2.03 0.044
5 1.86 0.036