Protein profile

KP13_01048

Inner membrane protein

Genome: KpKP13

Gene: AHE43424.1 Structure source: AlphaFold + ColabFold UniProt A0A0S3DB08
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Amino acids 309
Annotations 5
Features 29
PDB binders 2
Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession
KP13_01048
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43424.1
Status
annotated
Amino acids
309
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015499 Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87
Structure A0A0S3DB08
Pocket Pocket 1
P2Rank 0.387
Structure A0A0S3DB08
Pocket Pocket 1
ColabFold model
FPocket 0.679 · Pocket 15
P2Rank 0.391 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015499 Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

29 records
Show feature table
Start End DB Term Name
1 24 Coils Coil Coil
1 58 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
138 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
279 309 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
142 161 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
36 302 PANTHER PTHR30520 FORMATE TRANSPORTER-RELATED
36 302 InterPro IPR000292 Formate/nitrite transporter
80 98 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
36 273 FunFam G3DSA:1.20.1080.10:FF:000010 Inner membrane protein
59 79 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
256 278 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
210 215 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
237 255 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
43 279 Pfam PF01226 Formate/nitrite transporter
43 279 InterPro IPR000292 Formate/nitrite transporter
1 35 MobiDBLite mobidb-lite consensus disorder prediction
89 111 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
162 189 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
190 209 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
224 246 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
118 137 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
216 236 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
36 273 Gene3D G3DSA:1.20.1080.10 Glycerol uptake facilitator protein.
36 273 InterPro IPR023271 Aquaporin-like
256 278 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
99 117 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
60 79 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
195 217 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 15 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0S3DB08
AlphaFold — — full sequence — Viewing
ColabFold KP13_01048
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.87
11 0.31

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.7 0.206
2 4.45 0.189
3 2.44 0.066
4 1.53 0.023
5 1.42 0.018

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
HV6
7E27
O77389 312.2 Da LogP 3.22 TPSA 66.8 ✓ Ro5 ✓ Clean COc1ccc(c(c1)O)C(=O)/C=C(/C(C(F)(F)F)(F)F)\O
R7M
6VQR
O77389 312.2 Da LogP 2.55 TPSA 55.8 ✓ Ro5 ✓ Clean COc1ccc2c(c1)O[C@](CC2=O)(C(C(F)(F)F)(F)F)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.