Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_01022
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: dedD AHE43450.1
Status: annotated
Amino acids: 216
Structure source: AlphaFold + ColabFold

GO

GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0032506 A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: Unknown
ColabFold pLDDT: 66.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.012

Structure A0A0H3GWD7

Pocket Pocket 7

P2Rank

Structure A0A0H3GWD7

Pocket No pockets

ColabFold model

FPocket 0.193 · Pocket 8

P2Rank 0

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 81 / 4744 genomes with a hit

Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0042834 Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
GO:0030428 A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
GO:0032506 A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).
GO:0032153 The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records

Show feature table

Start	End	DB	Term	Name
136	211	SUPERFAMILY	SSF110997	Sporulation related repeat
136	211	InterPro	IPR036680	Sporulation-like domain superfamily
2	213	PANTHER	PTHR38687	CELL DIVISION PROTEIN DEDD-RELATED
134	213	ProSiteProfiles	PS51724	SPOR domain profile.
134	213	InterPro	IPR007730	Sporulation-like domain
136	211	Gene3D	G3DSA:3.30.70.1070	Sporulation related repeat
1	215	Hamap	MF_02022	Cell division protein DedD [dedD].
1	215	InterPro	IPR032898	Cell division protein DedD
11	16	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
1	16	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	16	SignalP_EUK	SignalP-noTM	SignalP-noTM
29	138	MobiDBLite	mobidb-lite	consensus disorder prediction
2	10	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
1	1	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
17	216	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
95	123	MobiDBLite	mobidb-lite	consensus disorder prediction
139	211	FunFam	G3DSA:3.30.70.1070:FF:000001	Cell division protein DedD
137	210	Pfam	PF05036	SPOR domain
137	210	InterPro	IPR007730	Sporulation-like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GWD7 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GWD7	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_01022	ColabFold	—	—	full sequence	—	Loaded

KP13_01022