Protein profile

KP13_01006

Phosphodiesterase

Genome: KpKP13

Gene: AHE43466.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR68
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Amino acids 188
Annotations 3
Features 14
PDB binders 0
Druggability 0.105

Overview

Basic information about this protein and its source genome.

Accession
KP13_01006
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43466.1
Status
annotated
Amino acids
188
Structure source
AlphaFold + ColabFold
EC
3.1.4.-
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.105
Structure A0A0H3GR68
Pocket Pocket 3
P2Rank 0.118
Structure A0A0H3GR68
Pocket Pocket 1
ColabFold model
FPocket 0.308 · Pocket 1
P2Rank 0.227 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 329 / 4744 genomes with a hit
Normalized 0.069

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
125 149 ProSitePatterns PS01269 Uncharacterized protein family UPF0025 signature.
125 149 InterPro IPR020935 Phosphodiesterase YfcE, conserved site
6 172 NCBIfam TIGR00040 YfcE family phosphodiesterase
6 172 InterPro IPR000979 Phosphodiesterase MJ0936/Vps29
7 166 CDD cd00841 MPP_YfcE
7 166 InterPro IPR041802 YfcE-like, metallophosphatase domain
5 188 Gene3D G3DSA:3.60.21.10 -
5 188 InterPro IPR029052 Metallo-dependent phosphatase-like
8 169 PANTHER PTHR11124 VACUOLAR SORTING PROTEIN VPS29
8 169 InterPro IPR000979 Phosphodiesterase MJ0936/Vps29
6 166 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain
6 166 InterPro IPR024654 Calcineurin-like phosphoesterase domain, lpxH-type
5 169 SUPERFAMILY SSF56300 Metallo-dependent phosphatases
5 169 InterPro IPR029052 Metallo-dependent phosphatase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR68
AlphaFold — — full sequence — Viewing
ColabFold KP13_01006
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.06 0.101