Protein profile

KP13_01005

putative Nudix hydrolase

Genome: KpKP13

Gene: AHE43467.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H120
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Amino acids 183
Annotations 2
Features 11
PDB binders 0
Druggability 0.071

Overview

Basic information about this protein and its source genome.

Accession
KP13_01005
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43467.1
Status
annotated
Amino acids
183
Structure source
AlphaFold + ColabFold
GO
GO:0016817 Catalysis of the hydrolysis of any acid anhydride. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
91.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.071
Structure A0A0H3H120
Pocket Pocket 4
P2Rank 0.859
Structure A0A0H3H120
Pocket Pocket 1
ColabFold model
FPocket 0.111 · Pocket 3
P2Rank 0.889 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 117 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
39 162 CDD cd04697 Nudix_Hydrolase_38
37 155 Pfam PF00293 NUDIX domain
37 155 InterPro IPR000086 NUDIX hydrolase domain
2 181 Gene3D G3DSA:3.90.79.10 Nucleoside Triphosphate Pyrophosphohydrolase
10 166 SUPERFAMILY SSF55811 Nudix
10 166 InterPro IPR015797 NUDIX hydrolase-like domain superfamily
1 171 PIRSF PIRSF017340 Nudix_hydro
1 171 InterPro IPR024195 NUDIX hydrolase, YfcD, predicted
36 164 ProSiteProfiles PS51462 Nudix hydrolase domain profile.
36 164 InterPro IPR000086 NUDIX hydrolase domain
3 152 PANTHER PTHR10885 ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H120
AlphaFold — — full sequence — Viewing
ColabFold KP13_01005
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.1 0.745
2 2.92 0.093