Protein profile

KP13_00963

Anaerobic glycerol-3-phosphate dehydrogenase subunit B

Genome: KpKP13

Gene: AHE43507.1 glpB Structure source: AlphaFold + ColabFold UniProt A0A0H3GVN0
Export view
Amino acids 419
Annotations 4
Features 17
PDB binders 0
Druggability 0.733

Overview

Basic information about this protein and its source genome.

Accession
KP13_00963
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43507.1 glpB
Status
annotated
Amino acids
419
Structure source
AlphaFold + ColabFold
EC
1.1.5.3
GO
GO:0004368 Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. GO:0009331 An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions. GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
95.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.733
Structure A0A0H3GVN0
Pocket Pocket 1
P2Rank 0.959
Structure A0A0H3GVN0
Pocket Pocket 1
ColabFold model
FPocket 0.766 · Pocket 1
P2Rank 0.961 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 69 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0004368 Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.
  • GO:0009331 An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions.
  • GO:0019563 The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 412 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain
1 412 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily
18 22 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
23 419 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
3 411 NCBIfam TIGR03378 anaerobic glycerol-3-phosphate dehydrogenase subunit GlpB
3 411 InterPro IPR009158 Glycerol-3-phosphate dehydrogenase, GlpB subunit
1 415 Hamap MF_00753 Anaerobic glycerol-3-phosphate dehydrogenase subunit B [glpB].
1 415 InterPro IPR009158 Glycerol-3-phosphate dehydrogenase, GlpB subunit
5 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
4 399 Pfam PF00890 FAD binding domain
4 399 InterPro IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain
1 22 Phobius SIGNAL_PEPTIDE Signal peptide region
1 417 PIRSF PIRSF000141 Anaerobic_G3P_dh
1 417 InterPro IPR009158 Glycerol-3-phosphate dehydrogenase, GlpB subunit
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 170 Gene3D G3DSA:3.50.50.60 -
1 170 InterPro IPR036188 FAD/NAD(P)-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVN0
AlphaFold — — full sequence — Viewing
ColabFold KP13_00963
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.733
15 0.275

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 26.38 0.913
2 2.6 0.075
3 0.88 0.004