Protein profile

KP13_00952

Sensor-like histidine kinase

Genome: KpKP13

Gene: AHE43520.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW72
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Amino acids 885
Annotations 6
Features 34
PDB binders 0
Druggability 0.906

Overview

Basic information about this protein and its source genome.

Accession
KP13_00952
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43520.1
Status
annotated
Amino acids
885
Structure source
AlphaFold + ColabFold
EC
2.7.2.-
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0009927 Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016774 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
82.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.906
Structure A0A0H3GW72
Pocket Pocket 1
P2Rank 0.536
Structure A0A0H3GW72
Pocket Pocket 1
ColabFold model
FPocket 0.537 · Pocket 13
P2Rank 0.647 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 71 / 4744 genomes with a hit
Normalized 0.015

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
  • GO:0009927 Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016774 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

34 records
Show feature table
Start End DB Term Name
16 26 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
325 885 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
797 884 Gene3D G3DSA:1.20.120.160 HPT domain
797 884 InterPro IPR036641 HPT domain superfamily
562 672 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
562 672 InterPro IPR003594 Histidine kinase/HSP90-like ATPase
806 866 Pfam PF01627 Hpt domain
806 866 InterPro IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain
1 38 Phobius SIGNAL_PEPTIDE Signal peptide region
1 15 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
493 679 PANTHER PTHR43047 TWO-COMPONENT HISTIDINE PROTEIN KINASE
504 674 SUPERFAMILY SSF55874 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
504 674 InterPro IPR036890 Histidine kinase/HSP90-like ATPase superfamily
803 884 CDD cd00088 HPT
803 884 InterPro IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain
15 37 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
464 674 ProSiteProfiles PS50109 Histidine kinase domain profile.
464 674 InterPro IPR005467 Histidine kinase domain
801 884 SUPERFAMILY SSF47226 Histidine-containing phosphotransfer domain, HPT domain
801 884 InterPro IPR036641 HPT domain superfamily
39 302 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
508 672 Gene3D G3DSA:3.30.565.10 -
508 672 InterPro IPR036890 Histidine kinase/HSP90-like ATPase superfamily
682 796 Gene3D G3DSA:3.40.50.11620 -
682 796 InterPro IPR038616 Phosphotransferase RcsD, RcsD-ABL domain superfamily
302 324 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
303 324 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
27 38 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
9 885 Hamap MF_00980 Phosphotransferase RcsD [rcsD].
9 885 InterPro IPR030861 Phosphotransferase RcsD
798 885 ProSiteProfiles PS50894 Histidine-containing phosphotransfer (HPt) domain profile.
798 885 InterPro IPR008207 Signal transduction histidine kinase, phosphotransfer (Hpt) domain
683 784 Pfam PF16359 RcsD-ABL domain
683 784 InterPro IPR032306 Phosphotransferase RcsD, RcsD-ABL domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW72
AlphaFold — — full sequence — Viewing
ColabFold KP13_00952
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.906

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.29 0.498
2 3.07 0.102
3 2.75 0.083
4 2.65 0.078
5 1.74 0.031