Protein profile

KP13_00942

Ecotin

Genome: KpKP13

Gene: eco AHE43531.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW64
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Amino acids 163
Annotations 2
Features 26
PDB binders 0
Druggability 0.241

Overview

Basic information about this protein and its source genome.

Accession
KP13_00942
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
eco AHE43531.1
Status
annotated
Amino acids
163
Structure source
AlphaFold + ColabFold
GO
GO:0004867 Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase. GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Periplasmic
ColabFold pLDDT
88.21

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.241
Structure A0A0H3GW64
Pocket Pocket 1
P2Rank
Structure A0A0H3GW64
Pocket No pockets
ColabFold model
FPocket 0.336 · Pocket 1
P2Rank 0.003 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004867 Binds to and stops, prevents or reduces the activity of a serine-type endopeptidase.
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
23 105 Gene3D G3DSA:2.60.40.550 Ecotin
1 23 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
4 163 Hamap MF_00706 Ecotin [eco].
4 163 InterPro IPR023084 Proteinase inhibitor I11, ecotin, gammaproteobacteria
22 105 FunFam G3DSA:2.60.40.550:FF:000001 Ecotin
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
24 163 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 16 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
106 163 FunFam G3DSA:4.10.1230.10:FF:000001 Ecotin
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
26 161 PANTHER PTHR35890 -
26 161 InterPro IPR005658 Proteinase inhibitor I11, ecotin
1 163 PIRSF PIRSF006865 Ecotin
1 163 InterPro IPR005658 Proteinase inhibitor I11, ecotin
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
106 163 Gene3D G3DSA:4.10.1230.10 Ecotin, trypsin inhibitor
106 163 InterPro IPR027438 Ecotin, C-terminal
31 153 Pfam PF03974 Ecotin
31 153 InterPro IPR005658 Proteinase inhibitor I11, ecotin
16 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
26 162 CDD cd00242 Ecotin
26 162 InterPro IPR023084 Proteinase inhibitor I11, ecotin, gammaproteobacteria
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
27 161 SUPERFAMILY SSF49772 Ecotin, trypsin inhibitor
27 161 InterPro IPR036198 Ecotin superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW64
AlphaFold — — full sequence — Viewing
ColabFold KP13_00942
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.241