Protein profile

KP13_04399

putative ABC transporter system permease protein

Genome: KpKP13

Gene: AHE43547.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GW54
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Amino acids 341
Annotations 4
Features 33
PDB binders 0
Druggability 0.814

Overview

Basic information about this protein and its source genome.

Accession
KP13_04399
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43547.1
Status
annotated
Amino acids
341
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042884 The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.044
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.814
Structure A0A0H3GW54
Pocket Pocket 4
P2Rank 0.474
Structure A0A0H3GW54
Pocket Pocket 1
ColabFold model
FPocket 0.934 · Pocket 12
P2Rank 0.346 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 187 / 4744 genomes with a hit
Normalized 0.039

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0042884 The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
1 340 PANTHER PTHR30325 MEMBRANE COMPONENT OF ABC TRANSPORTER
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
158 338 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
158 338 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
141 324 CDD cd06261 TM_PBP2
141 324 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
328 341 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
168 178 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
135 322 SUPERFAMILY SSF161098 MetI-like
135 322 InterPro IPR035906 MetI-like superfamily
259 286 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
21 42 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
306 328 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
223 258 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
203 222 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
142 167 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
142 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
131 335 Gene3D G3DSA:1.10.3720.10 -
131 335 InterPro IPR035906 MetI-like superfamily
254 276 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
177 199 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
287 305 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
306 327 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
198 202 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
43 141 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
203 222 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
179 197 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
130 334 FunFam G3DSA:1.10.3720.10:FF:000005 Microcin C ABC transporter permease
140 332 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
140 332 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
9 51 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
9 51 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GW54
AlphaFold — — full sequence — Viewing
ColabFold KP13_04399
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.814
11 0.554

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.55 0.513
2 4.05 0.162
3 1.78 0.033
4 1.24 0.012
5 0.96 0.005