Protein profile

KP13_04400

putative ABC transporter system permease protein

Genome: KpKP13

Gene: AHE43548.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR00
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Amino acids 364
Annotations 4
Features 31
PDB binders 0
Druggability 0.138

Overview

Basic information about this protein and its source genome.

Accession
KP13_04400
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43548.1
Status
annotated
Amino acids
364
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042884 The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
83.47

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.138
Structure A0A0H3GR00
Pocket Pocket 2
P2Rank 0.624
Structure A0A0H3GR00
Pocket Pocket 1
ColabFold model
FPocket 0.71 · Pocket 7
P2Rank 0.661 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 194 / 4744 genomes with a hit
Normalized 0.041

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0042884 The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
152 359 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
152 359 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
157 167 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
195 223 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
173 195 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
282 309 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 8 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
31 134 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
329 348 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
248 281 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
168 194 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 353 FunFam G3DSA:1.10.3720.10:FF:000014 Microcin C ABC transporter permease YejB
1 360 PANTHER PTHR30465 INNER MEMBRANE ABC TRANSPORTER
135 156 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
122 352 Gene3D G3DSA:1.10.3720.10 -
122 352 InterPro IPR035906 MetI-like superfamily
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
133 348 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
133 348 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
329 355 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
224 247 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
131 345 SUPERFAMILY SSF161098 MetI-like
131 345 InterPro IPR035906 MetI-like superfamily
356 364 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
133 152 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
133 350 CDD cd06261 TM_PBP2
133 350 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
310 328 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
224 246 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
9 30 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
283 305 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR00
AlphaFold — — full sequence — Viewing
ColabFold KP13_04400
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.29 0.645
2 5.63 0.271
3 3.44 0.124
4 2.26 0.056
5 1.44 0.019