Protein profile

KP13_31878

Lipoprotein spr

Genome: KpKP13

Gene: AHE43551.1 spr Structure source: AlphaFold + ColabFold UniProt A0A0W8AR57
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Amino acids 189
Annotations 6
Features 16
PDB binders 1
Druggability 0.224

Overview

Basic information about this protein and its source genome.

Accession
KP13_31878
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43551.1 spr
Status
annotated
Amino acids
189
Structure source
AlphaFold + ColabFold
EC
3.4.17.13 3.4.-.-
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008234 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0106415 GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
85.73

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.224
Structure A0A0W8AR57
Pocket Pocket 2
P2Rank 0.451
Structure A0A0W8AR57
Pocket Pocket 1
ColabFold model
FPocket 0.968 · Pocket 2
P2Rank 0.346 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 4 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008234 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
  • GO:0106415 GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 33 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 33 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
25 29 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
63 189 Gene3D G3DSA:3.90.1720.10 endopeptidase domain like (from Nostoc punctiforme)
1 13 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
80 184 Pfam PF00877 NlpC/P60 family
80 184 InterPro IPR000064 Endopeptidase, NLPC/P60 domain
20 188 PANTHER PTHR47360 MUREIN DD-ENDOPEPTIDASE MEPS/MUREIN LD-CARBOXYPEPTIDASE
65 186 ProSiteProfiles PS51935 NlpC/P60 domain profile.
65 186 InterPro IPR000064 Endopeptidase, NLPC/P60 domain
1 27 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
30 189 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
14 24 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 29 Phobius SIGNAL_PEPTIDE Signal peptide region
68 186 SUPERFAMILY SSF54001 Cysteine proteinases
68 186 InterPro IPR038765 Papain-like cysteine peptidase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0W8AR57
AlphaFold — — full sequence — Viewing
ColabFold KP13_31878
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.224

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.89 0.288
2 1.36 0.016

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FLC
7CFL
Q181Y8 189.1 Da LogP -5.25 TPSA 140.6 ✓ Ro5 ✓ Clean C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.