Protein profile

KP13_04405

CobW/P47K family protein

Genome: KpKP13

Gene: AHE43553.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQZ5
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Amino acids 325
Annotations 1
Features 12
PDB binders 0
Druggability 0.964

Overview

Basic information about this protein and its source genome.

Accession
KP13_04405
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43553.1
Status
annotated
Amino acids
325
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.275
Human E-value
3.09e-08
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
86.05

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.964
Structure A0A0H3GQZ5
Pocket Pocket 2
P2Rank 0.916
Structure A0A0H3GQZ5
Pocket Pocket 1
ColabFold model
FPocket 0.651 · Pocket 2
P2Rank 0.879 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
4 195 CDD cd03112 CobW-like
240 323 SMART SM00833 CobW_C_3
240 323 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal
242 321 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain
242 321 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal
6 163 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
6 163 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
5 164 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain
5 164 InterPro IPR003495 CobW/HypB/UreG, nucleotide-binding domain
2 193 Gene3D G3DSA:3.40.50.300 -
2 193 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
4 319 PANTHER PTHR13748 COBW-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQZ5
AlphaFold — — full sequence — Viewing
ColabFold KP13_04405
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.964
21 0.636
1 0.416
23 0.243

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.96 0.812
2 17.36 0.801
3 6.72 0.342