Protein profile

KP13_03206

LrgB-like protein

Genome: KpKP13

Gene: AHE43581.1 lrgB Structure source: AlphaFold + ColabFold UniProt A0A0H3H0T3
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Amino acids 231
Annotations 1
Features 24
PDB binders 0
Druggability 0.919

Overview

Basic information about this protein and its source genome.

Accession
KP13_03206
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43581.1 lrgB
Status
annotated
Amino acids
231
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.907
DEG E-value
1.89e-53
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.61

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.919
Structure A0A0H3H0T3
Pocket Pocket 2
P2Rank 0.31
Structure A0A0H3H0T3
Pocket Pocket 1
ColabFold model
FPocket 0.978 · Pocket 23
P2Rank 0.414 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 118 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
91 112 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
206 228 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
5 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
7 219 PANTHER PTHR30249 PUTATIVE SEROTONIN TRANSPORTER
7 219 InterPro IPR007300 CidB/LrgB family
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
34 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
12 224 Pfam PF04172 LrgB-like family
12 224 InterPro IPR007300 CidB/LrgB family
53 90 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
90 112 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
132 162 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
24 32 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
33 52 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
206 230 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 162 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
163 205 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
113 131 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 226 NCBIfam TIGR00659 CidB/LrgB family autolysis modulator
2 226 InterPro IPR005261 Inner membrane protein YohK-like
231 231 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0T3
AlphaFold — — full sequence — Viewing
ColabFold KP13_03206
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.919
9 0.437

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.54 0.331
2 2.33 0.06