Protein profile

KP13_03202

Beta-glucoside operon antiterminator

Genome: KpKP13

Gene: arbG AHE43585.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQW6
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Amino acids 303
Annotations 3
Features 24
PDB binders 0
Druggability 0.229

Overview

Basic information about this protein and its source genome.

Accession
KP13_03202
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
arbG AHE43585.1
Status
annotated
Amino acids
303
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003723 Binding to an RNA molecule or a portion thereof.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
87.03

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.229
Structure A0A0H3GQW6
Pocket Pocket 14
P2Rank 0.142
Structure A0A0H3GQW6
Pocket Pocket 1
ColabFold model
FPocket 0.46 · Pocket 1
P2Rank 0.279 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 55 / 4744 genomes with a hit
Normalized 0.012

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0045893 Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
27 80 Gene3D G3DSA:2.30.24.10 -
27 80 InterPro IPR036650 CAT RNA-binding domain superfamily
91 195 ProSiteProfiles PS51372 PRD domain profile.
91 195 InterPro IPR011608 PRD domain
26 299 PANTHER PTHR30185 CRYPTIC BETA-GLUCOSIDE BGL OPERON ANTITERMINATOR
193 301 Gene3D G3DSA:1.10.1790.10 PRD domain
85 192 SUPERFAMILY SSF63520 PTS-regulatory domain, PRD
85 192 InterPro IPR036634 PRD domain superfamily
113 187 Pfam PF00874 PRD domain
113 187 InterPro IPR011608 PRD domain
205 297 Pfam PF00874 PRD domain
205 297 InterPro IPR011608 PRD domain
196 299 SUPERFAMILY SSF63520 PTS-regulatory domain, PRD
196 299 InterPro IPR036634 PRD domain superfamily
90 192 Gene3D G3DSA:1.10.1790.10 PRD domain
27 85 SMART SM01061 CAT_RBD_2
27 85 InterPro IPR004341 CAT RNA-binding domain
123 135 ProSitePatterns PS00654 PRD domain signature.
123 135 InterPro IPR001550 Transcription antiterminator, conserved site
27 80 Pfam PF03123 CAT RNA binding domain
27 80 InterPro IPR004341 CAT RNA-binding domain
27 80 SUPERFAMILY SSF50151 SacY-like RNA-binding domain
196 303 ProSiteProfiles PS51372 PRD domain profile.
196 303 InterPro IPR011608 PRD domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQW6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03202
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.229

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.95 0.095