Protein profile

KP13_18568

Adenine deaminase

Genome: KpKP13

Gene: ade ANJ86597.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSQ0
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Amino acids 603
Annotations 5
Features 14
PDB binders 0
Druggability 0.865

Overview

Basic information about this protein and its source genome.

Accession
KP13_18568
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ade ANJ86597.1
Status
annotated
Amino acids
603
Structure source
AlphaFold + ColabFold
EC
3.5.4.2
GO
GO:0006146 The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. GO:0000034 Catalysis of the reaction: adenine + H+ + H2O = hypoxanthine + NH4+. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.865
Structure A0A0H3GSQ0
Pocket Pocket 28
P2Rank 0.933
Structure A0A0H3GSQ0
Pocket Pocket 1
ColabFold model
FPocket 0.973 · Pocket 31
P2Rank 0.933 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 34 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0006146 The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine.
  • GO:0000034 Catalysis of the reaction: adenine + H+ + H2O = hypoxanthine + NH4+.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
412 577 Pfam PF13382 Adenine deaminase C-terminal domain
412 577 InterPro IPR026912 Adenine deaminase C-terminal domain
76 326 SUPERFAMILY SSF51556 Metallo-dependent hydrolases
76 326 InterPro IPR032466 Metal-dependent hydrolase
22 582 Hamap MF_01518 Adenine deaminase [ade].
22 582 InterPro IPR006679 Adenine deaminase
76 321 Gene3D G3DSA:3.20.20.140 -
19 252 PANTHER PTHR11113 N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE
14 356 Gene3D G3DSA:2.30.40.10 Urease, subunit C, domain 1
14 356 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily
73 355 Pfam PF01979 Amidohydrolase family
73 355 InterPro IPR006680 Amidohydrolase-related
13 368 SUPERFAMILY SSF51338 Composite domain of metallo-dependent hydrolases
13 368 InterPro IPR011059 Metal-dependent hydrolase, composite domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSQ0
AlphaFold — — full sequence — Viewing
ColabFold KP13_18568
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
28 0.865
30 0.764
18 0.236

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 27.05 0.918
2 2.09 0.047
3 1.68 0.029