Genome KpKP13

Protein target profile

D-arabinitol transporter

Accession: KP13_03163

Gene: AHE43621.1 dalT 3D evidence: AlphaFold DB model + ColabFold model UniProt A0A0H3H0P3
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Length 425
Pocket druggability (P2Rank · AlphaFold DB model) 0.981
Functional annotation 0 EC 4 GO
Target summary

Promising target candidate with multiple supporting evidence streams.

Automated synthesis of the evidence currently loaded. Review the underlying records before prioritizing this protein.

Main supporting evidence

Independent pocket support: P2Rank + FPocket Both predictors report a high-scoring binding site (P2Rank 0.98, FPocket 0.88). Use the 3D pocket comparison to verify whether they identify the same site. No similar human protein detected The current BLAST sequence screen did not find a significant human match, lowering apparent off-target risk. Strong predicted binding pocket FPocket selected-pocket score 0.88. This is a computational pocket signal, not binding validation. Second pocket predictor agrees P2Rank predicted binding-site probability 0.98. Review the complete evidence below

Risks to review

Microbiome similarity 38 of 4744 screened genomes (0.8%) have a significant similarity hit. This target also has a predicted binding pocket (P2Rank 0.98) — check the ligand evidence before deprioritizing on off-target risk alone. Mixed conservation Core/accessory calls are not fully concordant.

Evidence gaps

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.
Terms and data sources used on this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal Target pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Prioritization evidence

Selectivity, essentiality, structural confidence, conservation, and predicted binding-site evidence.

Off-target risk

Human off-target
No hit
Gut microbiome similarity
0.8% of screened genomes Lower prevalence suggests narrower overlap with the screened gut microbiome.

Essentiality

Essential (DEG)
N
DEG identity (%)
0.0 Higher values support similarity to known essential genes.

Structure confidence

ColabFold pLDDT
86.53 0-100 confidence; >70 supports local structural interpretation.

Binding-site evidence

AlphaFold DB / UniProt model

P2Rank's binding-site probability is the primary druggability signal shown across the app; FPocket's druggability score is shown alongside it for comparison. Both estimate small-molecule pocket quality after applying the curated structure priority — neither is experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

Druggability (P2Rank) 0.981
Structure A0A0H3H0P3
Pocket Pocket 1
Druggability (FPocket) 0.876
Structure A0A0H3H0P3
Pocket Pocket 29
ColabFold model
P2Rank 0.986 · Pocket 1
FPocket 0.856 · Pocket 28
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 38 / 4744 genomes with a hit
Prevalence 0.8%

Cross-references

External database identifiers for this protein, its structures, ligands, and metabolic reactions.

Sequence

UniProt A0A0H3H0P3

Sequence

Primary amino-acid sequence viewer.

MSINNKQWLGLPLNLLWGYIAIAVFMTGDGFELAFLSHYIKALGFSPAEASFAFTLYGLAAALSAWISGVVAEIITPLKTMMIGFVLWCVFHVLFLVFGLGHANYALILLFYGIRGFAYPLFLYSFIVAIVHNVKSDNASSAIGWFWAVYSIGIGVFGSYIPSFTIPHIGEMGTLWLALAFCLTGGVIALVSLRHIQTPQHMQNLTTREKFSELGRAATLLYTNRNILLSSMVRIINTLSLFGFAVIMPMMFVDELGFSTSEWLQVWAVFFFTTIFSNVLWGILGEKLGWMKVVRWFGCIGMALSSLAFYYIPQHFGHSFAMALIPAIALGIFVAAFVPLAAVFPALEPKHKGAAISVYNLSAGMSNFLAPAIAVVLLPFFSTIGVVIAYTALYVVAFFLCAFIRVEQPGFSHKEATAREQVEFS

Functional annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Subcellular localization

Localization
CytoplasmicMembrane

Gene Ontology (GO)

4
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence domains and features

Domain and signature matches imported from InterPro and related databases.

51 records
Show feature table
Start End DB Term Name
162 172 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 415 SUPERFAMILY SSF103473 MFS general substrate transporter
6 415 InterPro IPR036259 MFS transporter superfamily
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
226 248 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
174 193 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
194 234 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
82 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
356 378 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
324 347 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
50 72 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
217 404 PANTHER PTHR23517 RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED
235 252 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
313 323 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
294 312 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
52 75 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
143 161 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
9 206 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
9 206 InterPro IPR036259 MFS transporter superfamily
17 405 CDD cd17337 MFS_CsbX
322 344 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
41 51 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
263 285 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
108 130 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
285 292 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
142 164 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
173 193 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
107 131 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 409 ProSiteProfiles PS50850 Major facilitator superfamily (MFS) profile.
1 409 InterPro IPR020846 Major facilitator superfamily domain
407 425 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
76 81 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
132 142 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
293 312 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
387 406 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 405 NCBIfam TIGR00897 RbtT/DalT/CsbX family MFS transporter
7 405 InterPro IPR004748 Polyol permease-like
1 15 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
348 358 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
221 414 Gene3D G3DSA:1.20.1250.20 MFS general substrate transporter like domains
221 414 InterPro IPR036259 MFS transporter superfamily
253 263 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
359 381 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
264 284 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 106 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
84 103 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 313 Pfam PF07690 Major Facilitator Superfamily
25 313 InterPro IPR011701 Major facilitator superfamily
382 386 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
382 404 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

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Pocket score High Medium Low
How colors and pocket overlays are used
Uniform protein color marks the displayed model as a single molecular object.
Experimental PDB structures may be colored by chain to distinguish subunits or copies present in the file.
Pocket colors and alpha spheres are evidence overlays for predicted binding cavities; they are not alternative protein chains.
'Alpha spheres' is FPocket's own cavity-shape geometry, imported when available and aligned with the loaded structure.
'Pocket atoms'/'Predicted site atoms' show the pocket's residue atoms instead: P2Rank reports residues rather than alpha spheres, and FPocket falls back to this when alpha-sphere geometry is unavailable or doesn't align.
'No pocket geometry' means neither alpha spheres nor residue-position data could be found for that pocket; the layer just highlights the same residues as 'Nearby residues'.
Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · P2Rank

Druggability (P2Rank): high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Pocket 1 P2Rank #1
0.981
Likely same site as FPocket 29 4.3 Å 32 shared residues 80% of smaller site
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Surrounding area
Pocket 2 P2Rank #2
0.824
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Surrounding area
Pocket 3 P2Rank #3
0.333
Likely same site as FPocket 29 7.5 Å 9 shared residues 82% of smaller site
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Surrounding area
Pocket 4 P2Rank #4
0.042
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Surrounding area
Pocket 5 P2Rank #5
0.035
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Surrounding area

Binding pockets · FPocket

Druggability (FPocket): high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Pocket 1 FPocket #29
0.876 Unusual size
Likely same site as P2Rank 1 4.3 Å 32 shared residues 80% of smaller site
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Surrounding area
All structural evidence 0 experimental · 2 predicted

Structural evidence

0 + 2

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold DB AF_A0A0H3H0P3
AlphaFold DB — — full sequence — Viewing
ColabFold KP13_03163
ColabFold — — full sequence — Loaded