Protein profile

KP13_03158

putative ABC transporter permease protein

Genome: KpKP13

Gene: AHE43626.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0N8
Export view
Amino acids 301
Annotations 3
Features 31
PDB binders 0
Druggability 0.87

Overview

Basic information about this protein and its source genome.

Accession
KP13_03158
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43626.1
Status
annotated
Amino acids
301
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
44.318
DEG E-value
2.53e-77
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.51

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.87
Structure A0A0H3H0N8
Pocket Pocket 2
P2Rank 0.541
Structure A0A0H3H0N8
Pocket Pocket 1
ColabFold model
FPocket 0.122 · Pocket 5
P2Rank 0.519 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 76 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
160 164 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
101 280 CDD cd06261 TM_PBP2
101 280 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
135 159 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 296 Gene3D G3DSA:1.10.3720.10 -
91 296 InterPro IPR035906 MetI-like superfamily
141 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
102 123 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 38 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
290 301 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
95 282 SUPERFAMILY SSF161098 MetI-like
95 282 InterPro IPR035906 MetI-like superfamily
165 182 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
118 299 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
118 299 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
183 228 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
36 72 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C
36 72 InterPro IPR025966 Oligopeptide transport permease C-like, N-terminal domain
268 289 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
230 247 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
124 134 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
229 248 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
62 101 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
32 300 PANTHER PTHR43386 OLIGOPEPTIDE TRANSPORT SYSTEM PERMEASE PROTEIN APPC
104 289 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
104 289 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
267 289 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
249 267 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0N8
AlphaFold — — full sequence — Viewing
ColabFold KP13_03158
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.87
19 0.613

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.21 0.549
2 2.75 0.084
3 1.91 0.039
4 1.34 0.015
5 1.19 0.01