Protein profile

KP13_03155

putative lipid kinase

Genome: KpKP13

Gene: AHE43629.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVW9
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Amino acids 298
Annotations 10
Features 25
PDB binders 0
Druggability 0.221

Overview

Basic information about this protein and its source genome.

Accession
KP13_03155
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43629.1
Status
annotated
Amino acids
298
Structure source
AlphaFold + ColabFold
EC
2.7.1.-
GO
GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0001727 Catalysis of the phosphorylation of a simple or complex lipid. GO:0046872 Binding to a metal ion. GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
28.205
Human E-value
8.76e-07
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
77.592
DEG E-value
9.45e-171
Localization
Cytoplasmic
ColabFold pLDDT
88.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.221
Structure A0A0H3GVW9
Pocket Pocket 7
P2Rank 0.425
Structure A0A0H3GVW9
Pocket Pocket 1
ColabFold model
FPocket 0.326 · Pocket 19
P2Rank 0.52 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 102 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 9 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

9
  • GO:0016310 The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
  • GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
  • GO:0001727 Catalysis of the phosphorylation of a simple or complex lipid.
  • GO:0046872 Binding to a metal ion.
  • GO:0008654 The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0000287 Binding to a magnesium (Mg) ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
7 298 Hamap MF_01377 Probable lipid kinase YegS [yegS].
7 298 InterPro IPR022433 Lipid kinase YegS
4 12 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
128 283 Gene3D G3DSA:2.60.200.40 -
8 297 NCBIfam TIGR03702 lipid kinase YegS
8 297 InterPro IPR022433 Lipid kinase YegS
17 298 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 16 Phobius SIGNAL_PEPTIDE Signal peptide region
9 128 Pfam PF00781 Diacylglycerol kinase catalytic domain
9 128 InterPro IPR001206 Diacylglycerol kinase, catalytic domain
3 127 Gene3D G3DSA:3.40.50.10330 -
3 127 InterPro IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
7 128 SMART SM00046 dagk_c4a_7
7 128 InterPro IPR001206 Diacylglycerol kinase, catalytic domain
13 16 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
8 295 SUPERFAMILY SSF111331 NAD kinase/diacylglycerol kinase-like
8 295 InterPro IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
3 132 ProSiteProfiles PS50146 DAG-kinase catalytic (DAGKc) domain profile.
3 132 InterPro IPR001206 Diacylglycerol kinase, catalytic domain
14 278 PANTHER PTHR12358 SPHINGOSINE KINASE
149 287 Pfam PF19279 YegS C-terminal NAD kinase beta sandwich-like domain
149 287 InterPro IPR045540 YegS/DAGK, C-terminal domain
2 292 NCBIfam TIGR00147 YegS/Rv2252/BmrU family lipid kinase
2 292 InterPro IPR005218 Diacylglycerol/lipid kinase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVW9
AlphaFold — — full sequence — Viewing
ColabFold KP13_03155
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.221

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.37 0.183