Protein profile

KP13_03154

putative protease

Genome: KpKP13

Gene: AHE43630.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQR9
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Amino acids 453
Annotations 4
Features 9
PDB binders 0
Druggability 0.604

Overview

Basic information about this protein and its source genome.

Accession
KP13_03154
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43630.1
Status
annotated
Amino acids
453
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
81.79

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.604
Structure A0A0H3GQR9
Pocket Pocket 1
P2Rank 0.844
Structure A0A0H3GQR9
Pocket Pocket 1
ColabFold model
FPocket 0.282 · Pocket 27
P2Rank 0.742 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 177 / 4744 genomes with a hit
Normalized 0.037

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
356 441 Gene3D G3DSA:2.40.30.10 Translation factors
1 408 PANTHER PTHR30217 PEPTIDASE U32 FAMILY
75 343 Pfam PF01136 Peptidase family U32
75 343 InterPro IPR001539 Peptidase U32
162 180 ProSitePatterns PS01276 Peptidase family U32 signature.
162 180 InterPro IPR001539 Peptidase U32
356 441 FunFam G3DSA:2.40.30.10:FF:000039 U32 family peptidase
359 440 Pfam PF16325 Peptidase family U32 C-terminal domain
359 440 InterPro IPR032525 Peptidase family U32, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQR9
AlphaFold — — full sequence — Viewing
ColabFold KP13_03154
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.604
2 0.301
27 0.035
3 0.034

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.67 0.844
2 5.56 0.22
3 4.8 0.175
4 4.39 0.152
5 1.74 0.026