Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_03148
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: mdtA AHE43636.1
Status: annotated
Amino acids: 412
Structure source: AlphaFold + ColabFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 79.036
DEG E-value: 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 86.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.162

Structure A0A0H3H0N0

Pocket Pocket 5

P2Rank

Structure A0A0H3H0N0

Pocket No pockets

ColabFold model

FPocket 0.143 · Pocket 10

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 121 / 4744 genomes with a hit

Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
86	134	Pfam	PF13533	Biotin-lipoyl like
86	134	InterPro	IPR039562	Membrane fusion protein, biotin-lipoyl like domain
1	410	Hamap	MF_01422	Multidrug resistance protein MdtA [mdtA].
1	410	InterPro	IPR022824	Multidrug resistance protein MdtA
9	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
389	412	MobiDBLite	mobidb-lite	consensus disorder prediction
27	412	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
299	391	Gene3D	G3DSA:2.40.420.20	-
79	298	Gene3D	G3DSA:2.40.30.170	-
120	193	Gene3D	G3DSA:1.10.287.470	Helix hairpin bin
85	229	Gene3D	G3DSA:2.40.50.100	-
126	153	Coils	Coil	Coil
1	8	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
4	393	PANTHER	PTHR30469	MULTIDRUG RESISTANCE PROTEIN MDTA
34	53	MobiDBLite	mobidb-lite	consensus disorder prediction
299	390	FunFam	G3DSA:2.40.420.20:FF:000001	Efflux RND transporter periplasmic adaptor subunit
120	193	FunFam	G3DSA:1.10.287.470:FF:000005	Multidrug resistance protein MdtA
9	26	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
78	312	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
61	389	NCBIfam	TIGR01730	efflux RND transporter periplasmic adaptor subunit
61	389	InterPro	IPR006143	RND efflux pump, membrane fusion protein
208	298	FunFam	G3DSA:2.40.30.170:FF:000006	Multidrug resistance protein MdtA
197	297	Pfam	PF13437	HlyD family secretion protein
391	405	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3H0N0 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3H0N0	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_03148	ColabFold	—	—	full sequence	—	Loaded

KP13_03148