Protein profile

KP13_03139

Protein AsmA

Genome: KpKP13

Gene: AHE43646.1 asmA Structure source: AlphaFold + ColabFold UniProt A0A0H3H0M4
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Amino acids 615
Annotations 2
Features 11
PDB binders 0
Druggability 0.873

Overview

Basic information about this protein and its source genome.

Accession
KP13_03139
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43646.1 asmA
Status
annotated
Amino acids
615
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0090313 Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.38

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.873
Structure A0A0H3H0M4
Pocket Pocket 65
P2Rank 0.997
Structure A0A0H3H0M4
Pocket Pocket 1
ColabFold model
FPocket 0.998 · Pocket 72
P2Rank 0.997 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 63 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0090313 Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
297 321 MobiDBLite mobidb-lite consensus disorder prediction
297 320 MobiDBLite mobidb-lite consensus disorder prediction
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 603 PANTHER PTHR30441 UNCHARACTERIZED
22 615 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
195 509 Pfam PF05170 AsmA family
195 509 InterPro IPR007844 AsmA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0M4
AlphaFold — — full sequence — Viewing
ColabFold KP13_03139
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
65 0.873
64 0.803
62 0.622

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 95.35 0.995
2 16.12 0.77
3 10.77 0.578
4 4.76 0.21
5 2.86 0.09