Protein profile

KP13_03806

putative tyrosine-protein kinase in cps region

Genome: KpKP13

Gene: AHE43657.1 wzc Structure source: AlphaFold + ColabFold UniProt A0A024GWE4
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Amino acids 718
Annotations 10
Features 24
PDB binders 1
Druggability 0.642

Overview

Basic information about this protein and its source genome.

Accession
KP13_03806
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43657.1 wzc
Status
annotated
Amino acids
718
Structure source
AlphaFold + ColabFold
EC
2.7.10.2 2.7.10.-
GO
GO:0045226 OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.642
Structure A0A024GWE4
Pocket Pocket 44
P2Rank 0.266
Structure A0A024GWE4
Pocket Pocket 1
ColabFold model
FPocket 0.756 · Pocket 33
P2Rank 0.63 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 77 / 4744 genomes with a hit
Normalized 0.016

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 EC 8 GO

Enzyme Commission (EC)

2

Gene Ontology (GO)

8
  • GO:0045226 OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0009103 The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0042802 Binding to an identical protein or proteins.
  • GO:0004715 Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
505 711 NCBIfam TIGR01007 polysaccharide biosynthesis tyrosine autokinase
505 711 InterPro IPR005702 Tyrosine-protein kinase wzc-like, C-terminal domain
365 445 Pfam PF13807 G-rich domain on putative tyrosine kinase
365 445 InterPro IPR032807 Tyrosine kinase, G-rich domain
423 445 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
55 422 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
267 294 Coils Coil Coil
505 694 CDD cd05387 BY-kinase
339 359 Coils Coil Coil
441 717 Gene3D G3DSA:3.40.50.300 -
441 717 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
423 447 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
31 53 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
448 718 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 30 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
536 650 Pfam PF13614 AAA domain
536 650 InterPro IPR025669 AAA domain
9 707 PANTHER PTHR32309 TYROSINE-PROTEIN KINASE
443 717 FunFam G3DSA:3.40.50.300:FF:000527 Tyrosine-protein kinase etk
31 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
15 105 Pfam PF02706 Chain length determinant protein
15 105 InterPro IPR003856 Polysaccharide chain length determinant N-terminal domain
523 702 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
523 702 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A024GWE4
AlphaFold — — full sequence — Viewing
ColabFold KP13_03806
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
44 0.642
6 0.256

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.14 0.236
2 3.28 0.114
3 3.15 0.107
4 2.91 0.093
5 2.17 0.051

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
PTR
6U1Q
Q9KTG5 261.2 Da LogP 0.11 TPSA 130.1 ✓ Ro5 ✓ Clean c1cc(ccc1C[C@@H](C(=O)O)N)OP(=O)(O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.