Protein profile

KP13_03804

putative glycosyltransferase family 2 in cps region

Genome: KpKP13

Gene: rfbN AHE43659.1 Structure source: AlphaFold + ColabFold UniProt A0A024GW46
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Amino acids 302
Annotations 2
Features 7
PDB binders 0
Druggability 0.265

Overview

Basic information about this protein and its source genome.

Accession
KP13_03804
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rfbN AHE43659.1
Status
annotated
Amino acids
302
Structure source
AlphaFold + ColabFold
GO
GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
55.592
DEG E-value
1.03e-114
Localization
Cytoplasmic
ColabFold pLDDT
97.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.265
Structure A0A024GW46
Pocket Pocket 14
P2Rank 0.991
Structure A0A024GW46
Pocket Pocket 1
ColabFold model
FPocket 0.556 · Pocket 16
P2Rank 0.991 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
  • GO:0044010 A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
5 235 PANTHER PTHR43685 GLYCOSYLTRANSFERASE
5 265 SUPERFAMILY SSF53448 Nucleotide-diphospho-sugar transferases
5 265 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
5 116 CDD cd00761 Glyco_tranf_GTA_type
3 212 Pfam PF13641 Glycosyltransferase like family 2
1 216 Gene3D G3DSA:3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
1 216 InterPro IPR029044 Nucleotide-diphospho-sugar transferases

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A024GW46
AlphaFold — — full sequence — Viewing
ColabFold KP13_03804
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.265

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 53.87 0.984
2 0.98 0.005