Protein profile

KP13_03779

putative glycosyltransferase group 1

Genome: KpKP13

Gene: AHE43686.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSH7
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Amino acids 376
Annotations 2
Features 9
PDB binders 4
Druggability 0.997

Overview

Basic information about this protein and its source genome.

Accession
KP13_03779
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43686.1
Status
annotated
Amino acids
376
Structure source
AlphaFold + ColabFold
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
69.333
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.79

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.997
Structure A0A0H3GSH7
Pocket Pocket 21
P2Rank 0.941
Structure A0A0H3GSH7
Pocket Pocket 1
ColabFold model
FPocket 0.955 · Pocket 17
P2Rank 0.731 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 6 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
27 371 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
22 375 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
3 150 Pfam PF13477 Glycosyl transferase 4-like
3 150 InterPro IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain
3 368 CDD cd03808 GT4_CapM-like
189 353 Pfam PF00534 Glycosyl transferases group 1
189 353 InterPro IPR001296 Glycosyl transferase, family 1
180 358 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
23 361 PANTHER PTHR12526 GLYCOSYLTRANSFERASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSH7
AlphaFold — — full sequence — Viewing
ColabFold KP13_03779
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
21 0.997

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 24.52 0.899
2 2.23 0.055

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

54 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
LIP
3C4V
Q8NTA6 258.1 Da LogP -4.98 TPSA 173.6 ✓ Ro5 ✓ Clean [C@H]1([C@@H](C([C@H]([C@@H](C1O)O)O)OP(=O)([O-…
MLT
3MBO
Q81ST7 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)O)C(=O)O
UD1
4WAD
A0A0D6HUA0 607.4 Da LogP -4.65 TPSA 305.9 3 viol. ✓ Clean CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O[P@@]…
UPG
2XA2
O58762 566.3 Da LogP -4.79 TPSA 297.0 3 viol. ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.