Protein profile

KP13_03764

hypothetical protein

Genome: KpKP13

Gene: AHE43699.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSG5
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Amino acids 274
Annotations 2
Features 13
PDB binders 0
Druggability 0.563

Overview

Basic information about this protein and its source genome.

Accession
KP13_03764
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE43699.1
Status
annotated
Amino acids
274
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029 Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.563
Structure A0A0H3GSG5
Pocket Pocket 2
P2Rank 0.226
Structure A0A0H3GSG5
Pocket Pocket 1
ColabFold model
FPocket 0.198 · Pocket 9
P2Rank 0.239 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004029 Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
4 259 CDD cd05266 SDR_a4
2 266 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
2 266 InterPro IPR036291 NAD(P)-binding domain superfamily
20 274 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 268 Gene3D G3DSA:3.40.50.720 -
4 14 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
15 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 243 PANTHER PTHR48079 PROTEIN YEEZ
10 212 Pfam PF01370 NAD dependent epimerase/dehydratase family
10 212 InterPro IPR001509 NAD-dependent epimerase/dehydratase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSG5
AlphaFold — — full sequence — Viewing
ColabFold KP13_03764
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.563
1 0.197
10 0.0
15 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.66 0.226
2 5.6 0.223